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grwd-1 Glutamate-rich WD repeat-containing protein 1 [ Caenorhabditis elegans ]

Gene ID: 175701, updated on 2-Nov-2024

Summary

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Official Symbol
grwd-1
Official Full Name
Glutamate-rich WD repeat-containing protein 1
Primary source
WormBase:WBGene00021899
Locus tag
CELE_Y54H5A.1
See related
AllianceGenome:WB:WBGene00021899
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in ribosome biogenesis. Predicted to be located in nucleus. Predicted to be active in nucleolus. Orthologous to human GRWD1 (glutamate rich WD repeat containing 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See grwd-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (5153543..5155436)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Protein HGH1 homolog Neighboring gene ncRNA Neighboring gene RNA-binding protein 42 Neighboring gene putative cytosolic Fe-S cluster assembly factor oxy-4 Neighboring gene pseudo Neighboring gene Trafficking protein particle complex subunit 2-like protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ribosome biogenesis disruption mediated chromatin structure changes revealed by SRAtac, a customizable end to end analysis pipeline for ATAC-seq. Freeman TF, et al. BMC Genomics, 2023 Sep 1. PMID 37658321, Free PMC Article
  2. [FeFe]-hydrogenase-like gene is involved in the regulation of sensitivity to oxygen in yeast and nematode. Fujii M, et al. Genes Cells, 2009 Apr. PMID 19335616
  3. Inhibition of ribosome biogenesis in the epidermis is sufficient to trigger organism-wide growth quiescence independently of nutritional status in C. elegans. Zhao Q, et al. PLoS Biol, 2023 Aug. PMID 37651423, Free PMC Article
  4. Gamma radiation induces life stage-dependent reprotoxicity in Caenorhabditis elegans via impairment of spermatogenesis. Maremonti E, et al. Sci Total Environ, 2019 Dec 10. PMID 31425988
  5. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in ribosome biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Glutamate-rich WD repeat-containing protein 1
NP_498091.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    5153543..5155436
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065690.8 → NP_498091.1  Glutamate-rich WD repeat-containing protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498091.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N393
    Conserved Domains (3) summary
    sd00039
    Location:232 → 273
    7WD40; WD40 repeat [structural motif]
    pfam12265
    Location:54 → 122
    CAF1C_H4-bd; Histone-binding protein RBBP4 or subunit C of CAF1 complex
    cl29593
    Location:182 → 401
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
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