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gars-1 Glycine--tRNA ligase [ Caenorhabditis elegans ]

Gene ID: 175703, updated on 2-Nov-2024

Summary

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Official Symbol
gars-1
Official Full Name
Glycine--tRNA ligase
Primary source
WormBase:WBGene00001744
Locus tag
CELE_T10F2.1
See related
AllianceGenome:WB:WBGene00001744
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable glycine-tRNA ligase activity and protein dimerization activity. Predicted to be involved in diadenosine tetraphosphate biosynthetic process and mitochondrial glycyl-tRNA aminoacylation. Predicted to be located in axon and extracellular region. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2D and autosomal dominant distal hereditary motor neuronopathy 5. Orthologous to human GARS1 (glycyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gars-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003281.10 (5159729..5163627, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene putative cytosolic Fe-S cluster assembly factor oxy-4 Neighboring gene pseudo Neighboring gene Trafficking protein particle complex subunit 2-like protein Neighboring gene Mitochondrial ornithine transporter 1 Neighboring gene Sentrin-specific protease

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A WHEP Domain Regulates the Dynamic Structure and Activity of Caenorhabditis elegans Glycyl-tRNA Synthetase. Chang CY, et al. J Biol Chem, 2016 Aug 5. PMID 27298321, Free PMC Article
  2. Proteomic analysis of Caenorhabditis elegans. Jeong PY, et al. Methods Mol Biol, 2009. PMID 19381582
  3. Conservation of caspase substrates across metazoans suggests hierarchical importance of signaling pathways over specific targets and cleavage site motifs in apoptosis. Crawford ED, et al. Cell Death Differ, 2012 Dec. PMID 22918439, Free PMC Article
  4. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article
  5. A global analysis of genetic interactions in Caenorhabditis elegans. Byrne AB, et al. J Biol, 2007. PMID 17897480, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A WHEP Domain Regulates the Dynamic Structure and Activity of Caenorhabditis elegans Glycyl-tRNA Synthetase.
    Title: A WHEP Domain Regulates the Dynamic Structure and Activity of Caenorhabditis elegans Glycyl-tRNA Synthetase.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycine-tRNA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein dimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in diadenosine tetraphosphate biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glycyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial glycyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Glycine--tRNA ligase
NP_001380013.1
  • Confirmed by transcript evidence
NP_498093.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    5159729..5163627 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065692.7 → NP_498093.1  Glycine--tRNA ligase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498093.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q10039
    Conserved Domains (1) summary
    PLN02734
    Location:69 → 742
    PLN02734; glycyl-tRNA synthetase

  2. NM_001392086.1 → NP_001380013.1  Glycine--tRNA ligase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8I711
    Conserved Domains (1) summary
    PLN02734
    Location:5 → 678
    PLN02734; glycyl-tRNA synthetase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q10039.2

Gene LinkOut

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