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cid-1 4Fe-4S ferredoxin-type domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 175707, updated on 2-Nov-2024

Summary

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Official Symbol
cid-1
Official Full Name
4Fe-4S ferredoxin-type domain-containing protein
Primary source
WormBase:WBGene00019629
Locus tag
CELE_K10D2.3
See related
AllianceGenome:WB:WBGene00019629
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables RNA uridylyltransferase activity. Involved in RNA 3' uridylation. Located in P granule; condensed nuclear chromosome; and perinuclear region of cytoplasm. Is expressed in germ line and intestine. Human ortholog(s) of this gene implicated in liver benign neoplasm. Orthologous to human TUT4 (terminal uridylyl transferase 4) and TUT7 (terminal uridylyl transferase 7). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cid-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
12
Sequence:
Chromosome: III; NC_003281.10 (5173922..5180507)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Anaphase-promoting complex subunit emb-1 Neighboring gene ncRNA Neighboring gene PAP-associated domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CDE-1 suppresses the production of risiRNA by coupling polyuridylation and degradation of rRNA. Wang Y, et al. BMC Biol, 2020 Sep 4. PMID 32887607, Free PMC Article
  2. CDE-1 affects chromosome segregation through uridylation of CSR-1-bound siRNAs. van Wolfswinkel JC, et al. Cell, 2009 Oct 2. PMID 19804759
  3. emb-1 encodes the APC16 subunit of the Caenorhabditis elegans anaphase-promoting complex. Shakes DC, et al. Genetics, 2011 Oct. PMID 21775471, Free PMC Article
  4. Reduced insulin/IGF-1 signalling upregulates two anti-viral immune pathways, decreases viral load and increases survival under viral infection in C. elegans. Duxbury EML, et al. Geroscience, 2024 Dec. PMID 38589671, Free PMC Article
  5. Using Diverse Model Systems to Define Intestinal Epithelial Defenses to Enteric Viral Infections. Segrist E, et al. Cell Host Microbe, 2020 Mar 11. PMID 32164844, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Screening by deep sequencing reveals mediators of microRNA tailing in C. elegans.
    Title: Screening by deep sequencing reveals mediators of microRNA tailing in C. elegans.
  2. CDE-1 suppresses the production of risiRNA by coupling polyuridylation and degradation of rRNA.
    Title: CDE-1 suppresses the production of risiRNA by coupling polyuridylation and degradation of rRNA.
  3. The cde-1 gene, K10D2.3, encodes the TRF-like nucleotidyltransferases CDE-1, study found that CDE-1 is required for the uridylation of CSR-1 bound siRNAs and chromosome segregation.
    Title: CDE-1 affects chromosome segregation through uridylation of CSR-1-bound siRNAs.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA uridylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA uridylyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA 3' uridylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA 3' uridylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in P granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
4Fe-4S ferredoxin-type domain-containing protein
NP_498099.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    5173922..5180507
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065698.6 → NP_498099.1  4Fe-4S ferredoxin-type domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498099.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q09409
    Conserved Domains (3) summary
    cd05402
    Location:1029 → 1151
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    COG5260
    Location:1034 → 1317
    TRF4; DNA polymerase sigma [Replication, recombination and repair]
    pfam03828
    Location:574 → 625
    PAP_assoc; Cid1 family poly A polymerase
Nucleotide Protein
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