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prx-10 Peroxisome biogenesis factor 10;Tryptophan--tRNA ligase, mitochondrial [ Caenorhabditis elegans ]

Gene ID: 175719, updated on 2-Nov-2024

Summary

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Official Symbol
prx-10
Official Full Name
Peroxisome biogenesis factor 10;Tryptophan--tRNA ligase, mitochondrial
Primary source
WormBase:WBGene00006946
Locus tag
CELE_C34E10.4
See related
AllianceGenome:WB:WBGene00006946
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable tryptophan-tRNA ligase activity. Predicted to be involved in mitochondrial tryptophanyl-tRNA aminoacylation. Predicted to be located in peroxisomal membrane. Predicted to be active in mitochondrial matrix. Orthologous to human WARS2 (tryptophanyl tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See prx-10 in Genome Data Viewer
Location:
chromosome: III
Exon count:
11
Sequence:
Chromosome: III; NC_003281.10 (5236410..5240055)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Protein arginine N-methyltransferase 5 Neighboring gene Small ribosomal subunit protein mS26 Neighboring gene Neurogenic differentiation factor 1 Neighboring gene Protein sumv-1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and dietary regulation of lipid droplet expansion in Caenorhabditis elegans. Zhang SO, et al. Proc Natl Acad Sci U S A, 2010 Mar 9. PMID 20176933, Free PMC Article
  2. A Genetic Screen for Mutants with Supersized Lipid Droplets in Caenorhabditis elegans. Li S, et al. G3 (Bethesda), 2016 Aug 9. PMID 27261001, Free PMC Article
  3. Endocrine pheromones couple fat rationing to dauer diapause through HNF4α nuclear receptors. Gao C, et al. Sci China Life Sci, 2021 Dec. PMID 34755252
  4. Modeling human peroxisome biogenesis disorders in the nematode Caenorhabditis elegans. Thieringer H, et al. J Cell Sci, 2003 May 1. PMID 12665560
  5. Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5. Kong J, et al. Nat Commun, 2020 Jan 29. PMID 31996685, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tryptophan-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tryptophan-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial tryptophanyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peroxisome organization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein import into peroxisome matrix IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in tryptophanyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Peroxisome biogenesis factor 10;Tryptophan--tRNA ligase, mitochondrial
NP_001021200.2
  • Confirmed by transcript evidence
NP_001379766.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    5236410..5240055
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026029.5 → NP_001021200.2  Peroxisome biogenesis factor 10 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021200.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C0HKD7, P46579, Q5TYM1, Q7Z259
    Conserved Domains (2) summary
    COG5574
    Location:162 → 308
    PEX10; RING-finger-containing E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
    pfam04757
    Location:18 → 222
    Pex2_Pex12; Pex2 / Pex12 amino terminal region

  2. NM_001392091.1 → NP_001379766.1  Tryptophan--tRNA ligase, mitochondrial [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C0HKD6
    Conserved Domains (1) summary
    PRK00927
    Location:34 → 360
    PRK00927; tryptophanyl-tRNA synthetase; Reviewed
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
C0HKD6.1
C0HKD7.1

Gene LinkOut

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Chemical Information
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