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gop-3 SAM50-like protein gop-3 [ Caenorhabditis elegans ]

Gene ID: 175723, updated on 2-Nov-2024

Summary

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Official Symbol
gop-3
Official Full Name
SAM50-like protein gop-3
Primary source
WormBase:WBGene00001662
Locus tag
CELE_C34E10.1
See related
AllianceGenome:WB:WBGene00001662
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in mitochondrial respiratory chain complex assembly and protein insertion into mitochondrial outer membrane. Predicted to be located in mitochondrial outer membrane. Human ortholog(s) of this gene implicated in metabolic dysfunction-associated steatotic liver disease. Orthologous to human SAMM50 (SAMM50 sorting and assembly machinery component). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gop-3 in Genome Data Viewer
Location:
chromosome: III
Exon count:
8
Sequence:
Chromosome: III; NC_003281.10 (5260694..5263837)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Protein CLEC16A homolog Neighboring gene GPN-loop GTPase 1 Neighboring gene Uncharacterized protein Neighboring gene Inosine triphosphate pyrophosphatase Neighboring gene C2H2-type domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology. Jian F, et al. Cell Rep, 2018 Jun 5. PMID 29874585
  2. Mitochondrial protein import determines lifespan through metabolic reprogramming and de novo serine biosynthesis. Lionaki E, et al. Nat Commun, 2022 Feb 3. PMID 35115503, Free PMC Article
  3. Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states. Tan D, et al. Elife, 2016 Mar 8. PMID 26952210, Free PMC Article
  4. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
  5. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in mitochondrial respiratory chain complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein insertion into mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in outer membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SAM50-like protein gop-3
NP_498119.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    5260694..5263837
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065718.8 → NP_498119.1  SAM50-like protein gop-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498119.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P46576, Q95UF7
    Conserved Domains (1) summary
    pfam01103
    Location:214 → 433
    Bac_surface_Ag; Surface antigen
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46576.2

Gene LinkOut

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