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ztf-8 C2H2-type domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 175726, updated on 2-Nov-2024

Summary

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Official Symbol
ztf-8
Official Full Name
C2H2-type domain-containing protein
Primary source
WormBase:WBGene00022598
Locus tag
CELE_ZC395.8
See related
AllianceGenome:WB:WBGene00022598
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metal ion binding activity. Involved in double-strand break repair. Located in condensed chromosome and nucleolus. Is expressed in several structures, including dorsal nerve cord; gonad; head muscle; head neurons; and intestine. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ztf-8 in Genome Data Viewer
Location:
chromosome: III
Exon count:
11
Sequence:
Chromosome: III; NC_003281.10 (5268755..5273471, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene C2H2-type domain-containing protein Neighboring gene ncRNA Neighboring gene Ovule protein Neighboring gene Uncharacterized protein Neighboring gene Co-chaperone protein daf-41 Neighboring gene similar to Transporter Of divalent Cations

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DNA Damage Sensitivity Assays in Caenorhabditis elegans. Kim HM, et al. Bio Protoc, 2015. PMID 26807430, Free PMC Article
  2. CRISPR-Cas9-Guided Genome Engineering in Caenorhabditis elegans. Kim HM, et al. Curr Protoc Mol Biol, 2019 Dec. PMID 31763794, Free PMC Article
  3. New Insights into the Post-Translational Regulation of DNA Damage Response and Double-Strand Break Repair in Caenorhabditis elegans. Kim HM, et al. Genetics, 2015 Jun. PMID 25819793, Free PMC Article
  4. PP2A inhibition causes synthetic lethality in BRCA2-mutated prostate cancer models via spindle assembly checkpoint reactivation. Wang J, et al. J Clin Invest, 2024 Jan 2. PMID 37934606, Free PMC Article
  5. ZTF-8 interacts with the 9-1-1 complex and is required for DNA damage response and double-strand break repair in the C. elegans germline. Kim HM, et al. PLoS Genet, 2014 Oct. PMID 25329393, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in double-strand break repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in condensed chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
C2H2-type domain-containing protein
NP_498124.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    5268755..5273471 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065723.7 → NP_498124.2  C2H2-type domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498124.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GYG1
Nucleotide Protein
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