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toc-1 similar to Transporter Of divalent Cations [ Caenorhabditis elegans ]

Gene ID: 175728, updated on 2-Nov-2024

Summary

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Official Symbol
toc-1
Official Full Name
similar to Transporter Of divalent Cations
Primary source
WormBase:WBGene00006590
Locus tag
CELE_ZC395.3
See related
AllianceGenome:WB:WBGene00006590
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable monoatomic cation transmembrane transporter activity. Predicted to be involved in zinc ion transport. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. Is expressed in nervous system. Orthologous to human SLC30A6 (solute carrier family 30 member 6). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See toc-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
6
Sequence:
Chromosome: III; NC_003281.10 (5275289..5277791)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene C2H2-type domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Co-chaperone protein daf-41 Neighboring gene 5-demethoxyubiquinone hydroxylase, mitochondrial Neighboring gene Transposase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The PP-motif in luminal loop 2 of ZnT transporters plays a pivotal role in TNAP activation. Fujimoto S, et al. Biochem J, 2016 Sep 1. PMID 27303047, Free PMC Article
  2. SLC30A10: A novel manganese transporter. Chen P, et al. Worm, 2015 Jul-Sep. PMID 26430566, Free PMC Article
  3. Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1. Ewbank JJ, et al. Science, 1997 Feb 14. PMID 9020081
  4. A global analysis of genetic interactions in Caenorhabditis elegans. Byrne AB, et al. J Biol, 2007. PMID 17897480, Free PMC Article
  5. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables monoatomic cation transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in monoatomic cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic cation transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in zinc ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in zinc ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
similar to Transporter Of divalent Cations
NP_001367624.1
  • Product from WormBase gene class toc;
    Confirmed by transcript evidence
NP_001379769.1
  • Product from WormBase gene class toc;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    5275289..5277791
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001379701.1 → NP_001367624.1  similar to Transporter Of divalent Cations [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q45EL5
    Conserved Domains (2) summary
    PRK13263
    Location:378 → 441
    ureE; urease accessory protein UreE; Provisional
    pfam01545
    Location:45 → 271
    Cation_efflux; Cation efflux family

  2. NM_001392094.1 → NP_001379769.1  similar to Transporter Of divalent Cations [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    O18272, Q23281
    Conserved Domains (2) summary
    PRK13263
    Location:360 → 423
    ureE; urease accessory protein UreE; Provisional
    pfam01545
    Location:27 → 253
    Cation_efflux; Cation efflux family
Nucleotide Protein
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