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disl-2 DIS3-like exonuclease 2 [ Caenorhabditis elegans ]

Gene ID: 175748, updated on 2-Nov-2024

Summary

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Official Symbol
disl-2
Official Full Name
DIS3-like exonuclease 2
Primary source
WormBase:WBGene00018612
Locus tag
CELE_F48E8.6
See related
AllianceGenome:WB:WBGene00018612
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable 3'-5'-RNA exonuclease activity. Involved in regulation of cell fate specification and regulation of development, heterochronic. Predicted to be located in cytoplasm. Predicted to be active in P-body. Human ortholog(s) of this gene implicated in Perlman syndrome and nephroblastoma. Orthologous to human DIS3L2 (DIS3 like 3'-5' exoribonuclease 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See disl-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
6
Sequence:
Chromosome: III; NC_003281.10 (5443167..5446506)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene NET domain-containing protein;Protein kinase domain-containing protein Neighboring gene DM2 domain-containing protein Neighboring gene F-box domain-containing protein Neighboring gene Hsp20/alpha crystallin family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RdRP-synthesized antisense ribosomal siRNAs silence pre-rRNA via the nuclear RNAi pathway. Zhou X, et al. Nat Struct Mol Biol, 2017 Mar. PMID 28165511
  2. CDE-1 suppresses the production of risiRNA by coupling polyuridylation and degradation of rRNA. Wang Y, et al. BMC Biol, 2020 Sep 4. PMID 32887607, Free PMC Article
  3. RNA surveillance is required for endoplasmic reticulum homeostasis. Sakaki K, et al. Proc Natl Acad Sci U S A, 2012 May 22. PMID 22562797, Free PMC Article
  4. Interaction between quality control systems for ER protein folding and RNA biogenesis. Sakaki K, et al. Worm, 2013 Apr 1. PMID 24058870, Free PMC Article
  5. CED-3 caspase acts with miRNAs to regulate non-apoptotic gene expression dynamics for robust development in C. elegans. Weaver BP, et al. Elife, 2014 Dec 30. PMID 25432023, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 3'-5'-RNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3'-5'-RNA exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in miRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear-transcribed mRNA catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in polyuridylation-dependent mRNA catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell fate specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of development, heterochronic IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in P-body IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DIS3-like exonuclease 2
NP_498160.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    5443167..5446506
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065759.7 → NP_498160.2  DIS3-like exonuclease 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498160.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09568
    Conserved Domains (2) summary
    COG0557
    Location:76 → 770
    VacB; Exoribonuclease R [Transcription]
    pfam00773
    Location:333 → 685
    RNB; RNB domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09568.2

Gene LinkOut

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