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dex-1 Dendrite extension defective protein 1 [ Caenorhabditis elegans ]

Gene ID: 175761, updated on 2-Nov-2024

Summary

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Official Symbol
dex-1
Official Full Name
Dendrite extension defective protein 1
Primary source
WormBase:WBGene00017028
Locus tag
CELE_D1044.2
See related
AllianceGenome:WB:WBGene00017028
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable calcium ion binding activity. Involved in amphid sensory organ dendrite retrograde extension. Located in dendrite membrane. Is expressed in anterior deirid sensillum; epithelial cell; excretory system; pharynx; and rectum. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dex-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
15
Sequence:
Chromosome: III; NC_003281.10 (5526104..5535507)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene putative kinase-like protein D1044.1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Epidermal Remodeling in Caenorhabditis elegans Dauers Requires the Nidogen Domain Protein DEX-1. Flatt KM, et al. Genetics, 2019 Jan. PMID 30409788, Free PMC Article
  2. DEX-1 and DYF-7 establish sensory dendrite length by anchoring dendritic tips during cell migration. Heiman MG, et al. Cell, 2009 Apr 17. PMID 19344940, Free PMC Article
  3. Epithelial Shaping by Diverse Apical Extracellular Matrices Requires the Nidogen Domain Protein DEX-1 in Caenorhabditis elegans. Cohen JD, et al. Genetics, 2019 Jan. PMID 30409789, Free PMC Article
  4. The glia of Caenorhabditis elegans. Oikonomou G, et al. Glia, 2011 Sep. PMID 21732423, Free PMC Article
  5. Axon guidance genes identified in a large-scale RNAi screen using the RNAi-hypersensitive Caenorhabditis elegans strain nre-1(hd20) lin-15b(hd126). Schmitz C, et al. Proc Natl Acad Sci U S A, 2007 Jan 16. PMID 17213328, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DEX-1 is a component of embryonic ECMs that shapes developing epithelia.
    Title: Epithelial Shaping by Diverse Apical Extracellular Matrices Requires the Nidogen Domain Protein DEX-1 in Caenorhabditis elegans.
  2. DEX-1 is an extracellular matrix component that plays a central role in C. elegans epidermal remodeling during dauer.
    Title: Epidermal Remodeling in Caenorhabditis elegans Dauers Requires the Nidogen Domain Protein DEX-1.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in amphid sensory organ dendrite retrograde extension IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in amphid sensory organ dendrite retrograde extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Dendrite extension defective protein 1
NP_001379843.1
  • Confirmed by transcript evidence
NP_498181.3
  • Partially confirmed by transcript evidence
NP_498182.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    5526104..5535507
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065781.6 → NP_498182.2  Dendrite extension defective protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498182.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D7SFI8, P41950, Q8TA75, Q95QP5, Q95QP6
    Conserved Domains (2) summary
    smart00539
    Location:163 → 304
    NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
    pfam12947
    Location:413 → 445
    EGF_3; EGF domain

  2. NM_001392098.1 → NP_001379843.1  Dendrite extension defective protein 1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    smart00539
    Location:146 → 287
    NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
    pfam12947
    Location:396 → 428
    EGF_3; EGF domain

  3. NM_065780.6 → NP_498181.3  Dendrite extension defective protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498181.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P41950
    Conserved Domains (2) summary
    smart00539
    Location:146 → 287
    NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
    pfam12947
    Location:396 → 428
    EGF_3; EGF domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41950.3

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