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mlc-3 EF-hand domain-containing protein;Myosin, essential light chain [ Caenorhabditis elegans ]

Gene ID: 175768, updated on 2-Nov-2024

Summary

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Official Symbol
mlc-3
Official Full Name
EF-hand domain-containing protein;Myosin, essential light chain
Primary source
WormBase:WBGene00003371
Locus tag
CELE_F09F7.2
See related
AllianceGenome:WB:WBGene00003371
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable calcium ion binding activity. Located in striated muscle myosin thick filament. Is expressed in body wall musculature; nervous system; non-striated muscle; and pharynx. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy 8. Orthologous to human MYL3 (myosin light chain 3) and MYL6B (myosin light chain 6B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mlc-3 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (5565025..5567382)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial Neighboring gene DNA-directed RNA polymerase subunit beta Neighboring gene Nematode Specific Peptide family, group B Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Profiling of Caenorhabditis elegans proteins using two-dimensional gel electrophoresis and matrix assisted laser desorption/ionization-time of flight-mass spectrometry. Kaji H, et al. Electrophoresis, 2000 May. PMID 10870962
  2. Molecular genetics of nematode muscle. Anderson P. Annu Rev Genet, 1989. PMID 2694942
  3. The embryonic muscle transcriptome of Caenorhabditis elegans. Fox RM, et al. Genome Biol, 2007. PMID 17848203, Free PMC Article
  4. Codon usage in Caenorhabditis elegans: delineation of translational selection and mutational biases. Stenico M, et al. Nucleic Acids Res, 1994 Jul 11. PMID 8041603, Free PMC Article
  5. Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states. Tan D, et al. Elife, 2016 Mar 8. PMID 26952210, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of muscle myosin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  
located_in striated muscle myosin thick filament HDA PubMed 

General protein information

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Preferred Names
EF-hand domain-containing protein;Myosin, essential light chain
NP_001359961.1
  • Confirmed by transcript evidence
NP_741145.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    5565025..5567382
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171128.8 → NP_741145.1  Myosin, essential light chain [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741145.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P53014
    UniProtKB/TrEMBL
    B6EU49
    Conserved Domains (2) summary
    pfam13499
    Location:9 → 70
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:90 → 142
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  2. NM_001372589.2 → NP_001359961.1  EF-hand domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G8JY79
    Conserved Domains (1) summary
    PTZ00184
    Location:10 → 43
    PTZ00184; calmodulin; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53014.1

Gene LinkOut

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