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ced-6 Cell death protein 6 [ Caenorhabditis elegans ]

Gene ID: 175773, updated on 2-Nov-2024

Summary

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Official Symbol
ced-6
Official Full Name
Cell death protein 6
Primary source
WormBase:WBGene00000420
Locus tag
CELE_F56D2.7
See related
AllianceGenome:WB:WBGene00000420
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables clathrin adaptor activity and scavenger receptor binding activity. Involved in several processes, including engulfment of apoptotic cell; left/right axis specification; and positive regulation of distal tip cell migration. Located in cytoplasmic side of plasma membrane and phagocytic vesicle. Orthologous to human GULP1 (GULP PTB domain containing engulfment adaptor 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ced-6 in Genome Data Viewer
Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (5595771..5598061)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Cytochrome b-c1 complex subunit 1, mitochondrial;Peptidase M16 C-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene WD repeat-containing protein 37 Neighboring gene MADF domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and characterization of a dimerization domain in CED-6, an adapter protein involved in engulfment of apoptotic cells. Su HP, et al. J Biol Chem, 2000 Mar 31. PMID 10734103
  2. Human CED-6 encodes a functional homologue of the Caenorhabditis elegans engulfment protein CED-6. Liu QA, et al. Curr Biol, 1999 Nov 18. PMID 10574771
  3. CED-6/GULP and components of the clathrin-mediated endocytosis machinery act redundantly to correctly display CED-1 on the cell membrane in Caenorhabditis elegans. Harders RH, et al. G3 (Bethesda), 2024 Jul 8. PMID 38696649, Free PMC Article
  4. Autophagosomes fuse to phagosomes and facilitate the degradation of apoptotic cells in Caenorhabditis elegans. Peña-Ramos O, et al. Elife, 2022 Jan 4. PMID 34982028, Free PMC Article
  5. Caenorhabditis elegans transthyretin-like protein TTR-52 mediates recognition of apoptotic cells by the CED-1 phagocyte receptor. Wang X, et al. Nat Cell Biol, 2010 Jul. PMID 20526330, Free PMC Article

See all (86) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables clathrin adaptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables scavenger receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in apoptotic process involved in development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in apoptotic process involved in development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in engulfment of apoptotic cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of mitotic spindle orientation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in left/right axis specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in phagocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic process involved in development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of apoptotic process involved in development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of distal tip cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of engulfment of apoptotic cell IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of engulfment of apoptotic cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Cell death protein 6
NP_498203.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    5595771..5598061
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065802.10 → NP_498203.2  Cell death protein 6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498203.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O01421, O76337
    Conserved Domains (1) summary
    cd01273
    Location:48 → 196
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O76337.1

Gene LinkOut

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