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daf-4 Cell surface receptor daf-4;Serine/threonine-protein kinase receptor;receptor protein serine/threonine kinase [ Caenorhabditis elegans ]

Gene ID: 175781, updated on 2-Nov-2024

Summary

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Official Symbol
daf-4
Official Full Name
Cell surface receptor daf-4;Serine/threonine-protein kinase receptor;receptor protein serine/threonine kinase
Primary source
WormBase:WBGene00000900
Locus tag
CELE_C05D2.1
See related
AllianceGenome:WB:WBGene00000900
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables BMP binding activity. Involved in several processes, including dauer entry; defense response to other organism; and regulation of BMP signaling pathway. Located in plasma membrane. Is expressed in several structures, including ganglia; intestine; somatic nervous system; tail hypodermis; and vulva. Used to study Marfan syndrome. Human ortholog(s) of this gene implicated in several diseases, including Loeys-Dietz syndrome 2; Lynch syndrome (multiple); Marfan syndrome; gastrointestinal system cancer (multiple); and mismatch repair cancer syndrome. Orthologous to several human genes including ACVR2B (activin A receptor type 2B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See daf-4 in Genome Data Viewer
Location:
chromosome: III
Exon count:
11
Sequence:
Chromosome: III; NC_003281.10 (5625135..5632322)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Aromatic-L-amino-acid decarboxylase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Calcium/calmodulin-dependent protein kinase kinase Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Biemamides A-E, Inhibitors of the TGF-β Pathway That Block the Epithelial to Mesenchymal Transition. Zhang F, et al. Org Lett, 2018 Sep 21. PMID 30160121, Free PMC Article
  2. Regulation of proteinase levels in the nematode Caenorhabditis elegans. Preferential depression by acute or chronic starvation. Hawdon JM, et al. Biochem J, 1989 Nov 15. PMID 2513805, Free PMC Article
  3. Characterization and cloning of a receptor for BMP-2 and BMP-4 from NIH 3T3 cells. Koenig BB, et al. Mol Cell Biol, 1994 Sep. PMID 8065329, Free PMC Article
  4. Monitoring of lipid storage in Caenorhabditis elegans using coherent anti-Stokes Raman scattering (CARS) microscopy. Hellerer T, et al. Proc Natl Acad Sci U S A, 2007 Sep 11. PMID 17804796, Free PMC Article
  5. Human Marfan and Marfan-like Syndrome associated mutations lead to altered trafficking of the Type II TGFβ receptor in Caenorhabditis elegans. Lin J, et al. PLoS One, 2019. PMID 31071172, Free PMC Article

See all (149) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TSP-12 and TSP-14 are required for the recycling of DAF-4/BMPRII.
    Title: Tetraspanins TSP-12 and TSP-14 function redundantly to regulate the trafficking of the type II BMP receptor in Caenorhabditis elegans.
  2. Our mutant daf-4 nematode models of Marfan syndrome (MFS) suggest that MFS and MFS-like mutations in the TGFB type II receptor lead to mis-trafficking of the receptor and possibly provides an explanation for the disease, a phenomenon which might also occur in some cancers that possess the same mutations within the type II receptor (e.g. colon cancer).
    Title: Human Marfan and Marfan-like Syndrome associated mutations lead to altered trafficking of the Type II TGFβ receptor in Caenorhabditis elegans.
  3. isolated dauer-formation mutations in C. briggsae, a species closely related to the model organism C. elegans and identified mutations in orthologs of C. elegans genes daf-2, daf-3 and daf-4
    Title: Genetic analysis of dauer formation in Caenorhabditis briggsae.
  4. alternative polyadenylation in intron 5 of daf-4 results in a 2.0 kb mRNA that encodes an open reading frame including only the N-terminal secretion signal and ligand-binding domains, and not the transmembrane or kinase domains
    Title: Alternative polyadenylation results in a truncated daf-4 BMP receptor that antagonizes DAF-7-mediated development in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables BMP binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transforming growth factor beta receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane receptor protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane receptor protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in BMP signaling pathway IC
Inferred by Curator
more info
 PubMed 
involved_in cell surface receptor protein serine/threonine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to growth factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dauer entry IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in dauer larval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in dauer larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to fungus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in larval feeding behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of dauer larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of nematode male tail tip morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of dauer larval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of dauer larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of eating behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mesodermal cell fate specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Cell surface receptor daf-4;Serine/threonine-protein kinase receptor;receptor protein serine/threonine kinase
NP_001021149.1
  • Confirmed by transcript evidence
NP_001309588.1
  • Confirmed by transcript evidence
NP_001317770.1
  • Confirmed by transcript evidence
NP_001379620.1
  • Confirmed by transcript evidence
NP_498211.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    5625135..5632322
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001322590.4 → NP_001309588.1  Serine/threonine-protein kinase receptor [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MB12
    Conserved Domains (3) summary
    smart00220
    Location:289 → 569
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam01684
    Location:146 → 192
    ET; ET module
    cl21453
    Location:289 → 582
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001392102.1 → NP_001379620.1  Serine/threonine-protein kinase receptor [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8ITX8
    Conserved Domains (1) summary
    cl21453
    Location:158 → 451
    PKc_like; Protein Kinases, catalytic domain

  3. NM_065810.8 → NP_498211.1  Cell surface receptor daf-4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498211.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O45139, P50488
    Conserved Domains (3) summary
    smart00220
    Location:310 → 590
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam01684
    Location:146 → 192
    ET; ET module
    cl21453
    Location:310 → 603
    PKc_like; Protein Kinases, catalytic domain

  4. NM_001025978.3 → NP_001021149.1  receptor protein serine/threonine kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021149.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G8JY02
    Conserved Domains (2) summary
    pfam01684
    Location:146 → 192
    ET; ET module
    cl21453
    Location:310 → 445
    PKc_like; Protein Kinases, catalytic domain

  5. NM_001330884.3 → NP_001317770.1  receptor protein serine/threonine kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MBJ8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50488.2

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