egg-1 LDL receptor repeat-containing protein egg-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: egg-1
Official Full Name: LDL receptor repeat-containing protein egg-1
Primary source: WormBase:WBGene00015083
Locus tag: CELE_B0244.8
See related: AllianceGenome:WB:WBGene00015083
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable signaling receptor activity. Involved in eggshell formation; positive regulation of protein localization to cell periphery; and single fertilization. Located in plasma membrane. Is expressed in germ line. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See egg-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 5

Sequence:: Chromosome: III; NC_003281.10 (5728180..5730159)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The egg surface LDL receptor repeat-containing proteins EGG-1 and EGG-2 are required for fertilization in Caenorhabditis elegans.
Title: The egg surface LDL receptor repeat-containing proteins EGG-1 and EGG-2 are required for fertilization in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B0244.8 (e-PCR)
- UniSTS:308358

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables signaling receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in eggshell formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein localization to cell cortex	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein localization to plasma membrane	IGI Inferred from Genetic Interaction more info	PubMed
involved_in single fertilization	IEA Inferred from Electronic Annotation more info
involved_in single fertilization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: LDL receptor repeat-containing protein egg-1

NP_498237.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

5728180..5730159

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065836.11 → NP_498237.2 LDL receptor repeat-containing protein egg-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498237.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09967

Conserved Domains (1) summary

cd00112
Location:216 → 251

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...