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dpff-1 Zinc finger protein dpff-1 [ Caenorhabditis elegans ]

Gene ID: 175832, updated on 2-Nov-2024

Summary

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Official Symbol
dpff-1
Official Full Name
Zinc finger protein dpff-1
Primary source
WormBase:WBGene00016200
Locus tag
CELE_C28H8.9
See related
AllianceGenome:WB:WBGene00016200
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metal ion binding activity. Involved in apoptotic process; meiotic cell cycle; and response to heat. Located in nucleus. Is expressed widely. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 7. Orthologous to several human genes including DPF2 (double PHD fingers 2) and DPF3 (double PHD fingers 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dpff-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003281.10 (5903563..5906346, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene Paxillin homolog 1 Neighboring gene ER lumen protein-retaining receptor erd-2.2 Neighboring gene putative helicase C28H8.3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DPFF-1 transcription factor deficiency causes the aberrant activation of MPK-1 and meiotic defects in the Caenorhabditis elegans germline. Villanueva-Chimal E, et al. Genesis, 2017 Nov. PMID 28940692
  2. Analysis of Caenorhabditis elegans phosphoproteome reveals the involvement of a molecular chaperone, HSP-90 protein during Salmonella enterica Serovar Typhi infection. Balasubramaniam B, et al. Int J Biol Macromol, 2019 Sep 15. PMID 31252012
  3. SWI/SNF chromatin remodeling regulates alcohol response behaviors in Caenorhabditis elegans and is associated with alcohol dependence in humans. Mathies LD, et al. Proc Natl Acad Sci U S A, 2015 Mar 10. PMID 25713357, Free PMC Article
  4. A 4D single-cell protein atlas of transcription factors delineates spatiotemporal patterning during embryogenesis. Ma X, et al. Nat Methods, 2021 Aug. PMID 34312566
  5. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gonads of dpff-1 null mutants showed more germ cells in pachytene, overexpressed the P-MPK-1 signal, produced less progeny and were more sensitive to heat shock.
    Title: DPFF-1 transcription factor deficiency causes the aberrant activation of MPK-1 and meiotic defects in the Caenorhabditis elegans germline.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of nBAF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Zinc finger protein dpff-1
NP_001122678.1
  • Confirmed by transcript evidence
NP_001359900.1
  • Confirmed by transcript evidence
NP_498281.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    5903563..5906346 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065880.8 → NP_498281.2  Zinc finger protein dpff-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498281.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8WFG1, H2KZ28, Q09247, Q09477
    Conserved Domains (4) summary
    COG5189
    Location:19 → 236
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    cd15526
    Location:257 → 311
    PHD1_MOZ_d4; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ), its factor (MORF), and d4 gene family proteins
    cd15530
    Location:313 → 358
    PHD2_d4; PHD finger 2 found in d4 gene family proteins
    pfam14051
    Location:3 → 77
    Requiem_N; N-terminal domain of DPF2/REQ

  2. NM_001372602.1 → NP_001359900.1  Zinc finger protein dpff-1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    pfam14051
    Location:3 → 77
    Requiem_N; N-terminal domain of DPF2/REQ

  3. NM_001129206.5 → NP_001122678.1  Zinc finger protein dpff-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122678.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09477
    Conserved Domains (1) summary
    pfam14051
    Location:3 → 77
    Requiem_N; N-terminal domain of DPF2/REQ
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09477.2

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