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ubq-1 Ubiquitin-related [ Caenorhabditis elegans ]

Gene ID: 175840, updated on 2-Nov-2024

Summary

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Official Symbol
ubq-1
Official Full Name
Ubiquitin-related
Primary source
WormBase:WBGene00006727
Locus tag
CELE_F25B5.4
See related
AllianceGenome:WB:WBGene00006727
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein tag activity and ubiquitin protein ligase binding activity. Involved in programmed cell death involved in cell development and ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm and nucleus. Is expressed in body wall musculature; hypodermis; and neurons. Orthologous to human UBC (ubiquitin C). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ubq-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (5940986..5943827)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Matrix metalloproteinase-A Neighboring gene Ovule protein Neighboring gene Uncharacterized protein Neighboring gene CDK5RAP1-like protein Neighboring gene Putative folylpolyglutamate synthase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Novel ubiquitin-like ribosomal protein fusion genes from the nematodes Caenorhabditis elegans and Caenorhabditis briggsae. Jones D, et al. J Biol Chem, 1993 Sep 15. PMID 7690036
  2. A portable regulatory element directs specific expression of the Caenorhabditis elegans ubiquitin gene ubq-2 in the somatic gonad. Jones D, et al. Dev Biol, 1995 Sep. PMID 7556908
  3. Conserved domains subserve novel mechanisms and functions in DKF-1, a Caenorhabditis elegans protein kinase D. Feng H, et al. J Biol Chem, 2006 Jun 30. PMID 16613842
  4. Impairment of the proteasome is crucial for glucose-induced lifespan reduction in the mev-1 mutant of Caenorhabditis elegans. Fitzenberger E, et al. Biochim Biophys Acta, 2013 Apr. PMID 23354069
  5. Proteins in aggregates functionally impact multiple neurodegenerative disease models by forming proteasome-blocking complexes. Ayyadevara S, et al. Aging Cell, 2015 Feb. PMID 25510159, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein tag activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in modification-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in programmed cell death involved in cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ubiquitin-related
NP_741157.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    5940986..5943827
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171139.8 → NP_741157.1  Ubiquitin-related [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741157.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P0CG71
    Conserved Domains (2) summary
    cd01803
    Location:77 → 152
    Ubiquitin; Ubiquitin
    smart00213
    Location:1 → 72
    UBQ; Ubiquitin homologues
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CG71.1

Gene LinkOut

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