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nfm-1 FERM domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 175870, updated on 2-Nov-2024

Summary

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Official Symbol
nfm-1
Official Full Name
FERM domain-containing protein
Primary source
WormBase:WBGene00003593
Locus tag
CELE_F42A10.2
See related
AllianceGenome:WB:WBGene00003593
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable actin binding activity and integrin binding activity. Predicted to be involved in several processes, including positive regulation of early endosome to late endosome transport; positive regulation of protein localization to early endosome; and regulation of hippo signaling. Predicted to be located in several cellular components, including anchoring junction; cytoplasm; and cytoskeleton. Predicted to be active in several cellular components, including adherens junction; apical part of cell; and filopodium. Is expressed in several structures, including excretory gland cell; hypodermis; intestine; non-striated muscle; and rectal gland cell. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); malignant pleural mesothelioma; meningioma (multiple); neurilemmoma; and vestibular schwannomatosis. Orthologous to human NF2 (NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nfm-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
12
Sequence:
Chromosome: III; NC_003281.10 (6159453..6164589)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene tRNA-Ser Neighboring gene ncRNA Neighboring gene tRNA-Ser Neighboring gene Gamma-glutamylcyclotransferase family protein Neighboring gene Eukaryotic elongation factor 2 kinase Neighboring gene Protein CDV3 homolog

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Caenorhabditis elegans NF2/Merlin Molecule NFM-1 Nonautonomously Regulates Neuroblast Migration and Interacts Genetically with the Guidance Cue SLT-1/Slit. Josephson MP, et al. Genetics, 2017 Feb. PMID 27913619, Free PMC Article
  2. Lumen morphogenesis in C. elegans requires the membrane-cytoskeleton linker erm-1. Göbel V, et al. Dev Cell, 2004 Jun. PMID 15177034
  3. The Hippo Pathway Is Essential for Maintenance of Apicobasal Polarity in the Growing Intestine of Caenorhabditis elegans. Lee H, et al. Genetics, 2019 Oct. PMID 31358532, Free PMC Article
  4. The C. elegans ezrin-radixin-moesin protein ERM-1 is necessary for apical junction remodelling and tubulogenesis in the intestine. Van Fürden D, et al. Dev Biol, 2004 Aug 1. PMID 15242805
  5. Epithelial junctions and attachments. Labouesse M. WormBook, 2006 Jan 13. PMID 18050482, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In summary, we have delineated the conserved Hippo pathway in C. elegans consisting of NFM-1-WTS-1-YAP-1-EGL-44 and proved that the proper regulation of YAP-1 by upstream NFM-1 and WTS-1 is essential for maintenance of apicobasal membrane identities of the growing intestine
    Title: The Hippo Pathway Is Essential for Maintenance of Apicobasal Polarity in the Growing Intestine of Caenorhabditis elegans.
  2. NFM-1 is required nonautonomously, possibly in muscles, to promote Q lineage migrations. NFM-1 genetically interacts with SLT-1.
    Title: The Caenorhabditis elegans NF2/Merlin Molecule NFM-1 Nonautonomously Regulates Neuroblast Migration and Interacts Genetically with the Guidance Cue SLT-1/Slit.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
  
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of early endosome to late endosome transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of protein localization to early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of gliogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of organelle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
  
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
is_active_in apical part of cell IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in filopodium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
FERM domain-containing protein
NP_001022571.1
  • Confirmed by transcript evidence
NP_498335.1
  • Confirmed by transcript evidence
NP_498336.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    6159453..6164589
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065934.5 → NP_498335.1  FERM domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498335.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KYX2
    Conserved Domains (5) summary
    smart00295
    Location:16 → 216
    B41; Band 4.1 homologues
    cd13194
    Location:210 → 304
    FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
    pfam09606
    Location:464 → 608
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam00769
    Location:339 → 432
    ERM; Ezrin/radixin/moesin family
    pfam15991
    Location:320 → 526
    G_path_suppress; G-protein pathway suppressor

  2. NM_065935.5 → NP_498336.1  FERM domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498336.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KYX3
    Conserved Domains (5) summary
    smart00295
    Location:16 → 216
    B41; Band 4.1 homologues
    cd13194
    Location:210 → 304
    FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
    pfam09606
    Location:464 → 608
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam00769
    Location:339 → 432
    ERM; Ezrin/radixin/moesin family
    pfam15991
    Location:320 → 526
    G_path_suppress; G-protein pathway suppressor

  3. NM_001027400.4 → NP_001022571.1  FERM domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022571.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5LK46
    Conserved Domains (5) summary
    smart00295
    Location:16 → 216
    B41; Band 4.1 homologues
    cd13194
    Location:210 → 304
    FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
    pfam09606
    Location:464 → 608
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam00769
    Location:339 → 432
    ERM; Ezrin/radixin/moesin family
    pfam15991
    Location:320 → 526
    G_path_suppress; G-protein pathway suppressor
Nucleotide Protein
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