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efk-1 Eukaryotic elongation factor 2 kinase [ Caenorhabditis elegans ]

Gene ID: 175871, updated on 2-Nov-2024

Summary

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Official Symbol
efk-1
Official Full Name
Eukaryotic elongation factor 2 kinase
Primary source
WormBase:WBGene00001160
Locus tag
CELE_F42A10.4
See related
AllianceGenome:WB:WBGene00001160
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables elongation factor-2 kinase activity. Predicted to be involved in myosin II filament disassembly. Orthologous to human EEF2K (eukaryotic elongation factor 2 kinase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See efk-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
6
Sequence:
Chromosome: III; NC_003281.10 (6164906..6168547, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene tRNA-Ser Neighboring gene FERM domain-containing protein Neighboring gene Gamma-glutamylcyclotransferase family protein Neighboring gene Protein CDV3 homolog Neighboring gene ncRNA Neighboring gene ABC transporter domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Adaptation to starvation: translating a matter of life or death. Manning BD. Cancer Cell, 2013 Jun 10. PMID 23763997
  2. Regulation of the Elongation Phase of Protein Synthesis Enhances Translation Accuracy and Modulates Lifespan. Xie J, et al. Curr Biol, 2019 Mar 4. PMID 30773367
  3. [Surviving nutrient deprivation by restraining translation elongation: biological function of the eEF2 kinase]. Leprivier G, et al. Med Sci (Paris), 2013 Nov. PMID 24280494
  4. Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity. Jan A, et al. Acta Neuropathol Commun, 2018 Jul 2. PMID 29961428, Free PMC Article
  5. Whole genome profiling of short-term hypoxia induced genes and identification of HIF-1 binding sites provide insights into HIF-1 function in Caenorhabditis elegans. Feng D, et al. PLoS One, 2024. PMID 38743782, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. eEF2K enhances the accuracy of protein synthesis under a range of conditions and in several cell types. Activation of eEF2K decreases misreading or termination readthrough errors during elongation, whereas knocking down or knocking out eEF2K increases their frequency.
    Title: Regulation of the Elongation Phase of Protein Synthesis Enhances Translation Accuracy and Modulates Lifespan.
  2. Genetic deletion of the eEF2K ortholog efk-1 reduced oxidative stress, and improved chemotaxis and serotonin sensitivity in C. elegans expressing human Abeta42 in neurons. Study highlights the potential utility of eEF2K inhibition to reduce Abeta-mediated oxidative stress in Alzheimer's disease.
    Title: eEF2K inhibition blocks Aβ42 neurotoxicity by promoting an NRF2 antioxidant response.
  3. C. elegans strains deficient in efk-1, the eEF2K ortholog, were severely compromised in their response to nutrient depletion.
    Title: The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables elongation factor-2 kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables elongation factor-2 kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables elongation factor-2 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in myosin II filament disassembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Eukaryotic elongation factor 2 kinase
NP_001022572.1
  • Confirmed by transcript evidence
NP_001022573.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    6164906..6168547 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027402.6 → NP_001022573.1  Eukaryotic elongation factor 2 kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022573.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O01991
    Conserved Domains (2) summary
    smart00811
    Location:106 → 301
    Alpha_kinase; Alpha-kinase family
    sd00010
    Location:666 → 716
    SLR; SLR repeat [structural motif]

  2. NM_001027401.4 → NP_001022572.1  Eukaryotic elongation factor 2 kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022572.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O01991, O01992, Q20309, Q8MYP9
    Conserved Domains (2) summary
    smart00811
    Location:106 → 301
    Alpha_kinase; Alpha-kinase family
    sd00010
    Location:674 → 724
    SLR; SLR repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O01991.1

Gene LinkOut

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