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rpn-2 26S proteasome non-ATPase regulatory subunit 1 [ Caenorhabditis elegans ]

Gene ID: 175877, updated on 2-Nov-2024

Summary

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Official Symbol
rpn-2
Official Full Name
26S proteasome non-ATPase regulatory subunit 1
Primary source
WormBase:WBGene00004459
Locus tag
CELE_C23G10.4
See related
AllianceGenome:WB:WBGene00004459
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protein kinase C binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in several cellular components, including cell cortex; mitotic spindle; and nuclear membrane. Is expressed in intestine. Orthologous to human PSMD1 (proteasome 26S subunit, non-ATPase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rpn-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003281.10 (6199184..6202594)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene putative tRNA (uracil-O(2)-)-methyltransferase Neighboring gene NADAR domain-containing protein Neighboring gene Small ribosomal subunit protein uS3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Symmetrically dividing cell specific division axes alteration observed in proteasome depleted C. elegans embryo. Sugiyama Y, et al. Mech Dev, 2008 Aug. PMID 18502617
  2. A bacterial metabolite induces glutathione-tractable proteostatic damage, proteasomal disturbances, and PINK1-dependent autophagy in C. elegans. Martinez BA, et al. Cell Death Dis, 2015 Oct 15. PMID 26469957, Free PMC Article
  3. Exploring transcriptional conservation between Ancylostoma caninum and Haemonchus contortus by oligonucleotide microarray and bioinformatic analyses. Cantacessi C, et al. Mol Cell Probes, 2009 Feb. PMID 18977290
  4. The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans. Choe KP, et al. Mol Cell Biol, 2009 May. PMID 19273594, Free PMC Article
  5. Proteasome activity contributes to pro-survival response upon mild mitochondrial stress in Caenorhabditis elegans. Sladowska M, et al. PLoS Biol, 2021 Jul. PMID 34252079, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables enzyme regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase C binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome regulatory particle, base subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in proteasome storage granule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
26S proteasome non-ATPase regulatory subunit 1
NP_001379706.1
  • Confirmed by transcript evidence
NP_498346.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    6199184..6202594
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065945.7 → NP_498346.2  26S proteasome non-ATPase regulatory subunit 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498346.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q18114, Q18115
    Conserved Domains (3) summary
    COG5116
    Location:38 → 959
    RPN2; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
    pfam01851
    Location:630 → 663
    PC_rep; Proteasome/cyclosome repeat
    sd00044
    Location:577 → 606
    HEAT; HEAT repeat [structural motif]

  2. NM_001392118.1 → NP_001379706.1  26S proteasome non-ATPase regulatory subunit 1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    COG5116
    Location:38 → 833
    RPN2; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
    sd00044
    Location:577 → 606
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q18115.4

Gene LinkOut

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