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esyt-2 C2 domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 175882, updated on 2-Nov-2024

Summary

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Official Symbol
esyt-2
Official Full Name
C2 domain-containing protein
Primary source
WormBase:WBGene00020443
Locus tag
CELE_T12A2.15
See related
AllianceGenome:WB:WBGene00020443
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable calcium ion binding activity and phospholipid binding activity. Predicted to be active in endoplasmic reticulum membrane. Is expressed in body wall musculature; gonad; nervous system; and pharynx. Orthologous to several human genes including ESYT2 (extended synaptotagmin 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See esyt-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
18
Sequence:
Chromosome: III; NC_003281.10 (6224436..6229403, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Neuropeptide-Like Protein Neighboring gene ncRNA Neighboring gene Homolog of Odr-2 (Two) Neighboring gene Uncharacterized protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Caenorhabditis elegans junctophilin has tissue-specific functions and regulates neurotransmission with extended-synaptotagmin. Piggott CA, et al. Genetics, 2021 Aug 9. PMID 33871019, Free PMC Article
  2. PDZD-8 and TEX-2 regulate endosomal PI(4,5)P(2) homeostasis via lipid transport to promote embryogenesis in C. elegans. Jeyasimman D, et al. Nat Commun, 2021 Oct 18. PMID 34663803, Free PMC Article
  3. Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Skop AR, et al. Science, 2004 Jul 2. PMID 15166316, Free PMC Article
  4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Caenorhabditis elegans junctophilin has tissue-specific functions and regulates neurotransmission with extended-synaptotagmin.
    Title: Caenorhabditis elegans junctophilin has tissue-specific functions and regulates neurotransmission with extended-synaptotagmin.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylcholine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylethanolamine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
C2 domain-containing protein
NP_001366808.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    6224436..6229403 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001379752.3 → NP_001366808.1  C2 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A679L8R0
    Conserved Domains (4) summary
    cd04050
    Location:424 → 528
    C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
    cd08391
    Location:276 → 394
    C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
    smart00239
    Location:691 → 800
    C2; Protein kinase C conserved region 2 (CalB)
    pfam17047
    Location:83 → 260
    SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain
Nucleotide Protein
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