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stt-3 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit stt-3 [ Caenorhabditis elegans ]

Gene ID: 175886, updated on 2-Nov-2024

Summary

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Official Symbol
stt-3
Official Full Name
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit stt-3
Primary source
WormBase:WBGene00020437
Locus tag
CELE_T12A2.2
See related
AllianceGenome:WB:WBGene00020437
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable dolichyl-diphosphooligosaccharide-protein glycotransferase activity. Predicted to be involved in post-translational protein modification and protein N-linked glycosylation via asparagine. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ix. Orthologous to human STT3B (STT3 oligosaccharyltransferase complex catalytic subunit B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See stt-3 in Genome Data Viewer
Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (6248642..6251607)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene GEN1 Holliday junction resolvase homolog Neighboring gene ncRNA Neighboring gene putative imidazolonepropionase Neighboring gene Serpentine receptor class gamma-8 Neighboring gene ncRNA Neighboring gene Serpentine receptor class gamma-9

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase is indispensable for oogenesis, oocyte-to-embryo transition, and larval development of the nematode Caenorhabditis elegans. Kanaki N, et al. Glycobiology, 2019 Feb 1. PMID 30445613, Free PMC Article
  2. Identification of a novel ADAMTS9/GON-1 function for protein transport from the ER to the Golgi. Yoshina S, et al. Mol Biol Cell, 2012 May. PMID 22419820, Free PMC Article
  3. RNAi screening of human glycogene orthologs in the nematode Caenorhabditis elegans and the construction of the C. elegans glycogene database. Akiyoshi S, et al. Glycobiology, 2015 Jan. PMID 25091817, Free PMC Article
  4. Carbohydrates and glycosylation. Berninsone PM. WormBook, 2006 Dec 18. PMID 18050430, Free PMC Article
  5. The RNA-binding protein repertoire of Arabidopsis thaliana. Marondedze C, et al. Sci Rep, 2016 Jul 11. PMID 27405932, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables dolichyl-diphosphooligosaccharide-protein glycotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dolichyl-diphosphooligosaccharide-protein glycotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oligosaccharyl transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in post-translational protein modification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation via asparagine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit stt-3
NP_498362.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    6248642..6251607
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065961.6 → NP_498362.1  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit stt-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498362.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P46975
    Conserved Domains (2) summary
    COG1287
    Location:22 → 751
    Stt3; Asparagine N-glycosylation enzyme, membrane subunit Stt3 [Posttranslational modification, protein turnover, chaperones]
    pfam02516
    Location:19 → 506
    STT3; Oligosaccharyl transferase STT3 subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46975.1

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