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F47D12.7 Kelch repeat and BTB domain-containing protein F47D12.7 [ Caenorhabditis elegans ]

Gene ID: 175891, updated on 2-Nov-2024

Summary

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Official Symbol
F47D12.7
Official Full Name
Kelch repeat and BTB domain-containing protein F47D12.7
Primary source
WormBase:WBGene00018563
Locus tag
CELE_F47D12.7
See related
AllianceGenome:WB:WBGene00018563
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in spermatogenic failure 11. Orthologous to human KLHL10 (kelch like family member 10). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See F47D12.7 in Genome Data Viewer
Location:
chromosome: III
Exon count:
13
Sequence:
Chromosome: III; NC_003281.10 (6293247..6296022, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene High mobility group protein 1.2 Neighboring gene Gastrulation-defective protein 3 Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene WD_REPEATS_REGION domain-containing protein;putative WD repeat-containing protein F47D12.9 Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein;Muscarinic acetylcholine receptor gar-2 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Kelch repeat and BTB domain-containing protein F47D12.7
NP_498380.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    6293247..6296022 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065979.4 → NP_498380.1  Kelch repeat and BTB domain-containing protein F47D12.7 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498380.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09563
    Conserved Domains (5) summary
    smart00612
    Location:369 → 415
    Kelch; Kelch domain
    smart00875
    Location:159 → 228
    BACK; BTB And C-terminal Kelch
    PHA03098
    Location:44 → 554
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:306 → 349
    Kelch; KELCH repeat [structural motif]
    cl02518
    Location:41 → 138
    BTB; BTB/POZ domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09563.1

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