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jhdm-1 JmjC domain-containing histone demethylation protein 1 [ Caenorhabditis elegans ]

Gene ID: 175919, updated on 2-Nov-2024

Summary

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Official Symbol
jhdm-1
Official Full Name
JmjC domain-containing histone demethylation protein 1
Primary source
WormBase:WBGene00020821
Locus tag
CELE_T26A5.5
See related
AllianceGenome:WB:WBGene00020821
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable histone demethylase activity and transcription coregulator activity. Predicted to be involved in chromatin remodeling and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in intestine; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to several human genes including KDM2B (lysine demethylase 2B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See jhdm-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
14
Sequence:
Chromosome: III; NC_003281.10 (6454483..6460014)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene UDENN domain-containing protein Neighboring gene Histone-lysine N-methyltransferase set-1;SET domain-containing protein Neighboring gene ncRNA Neighboring gene Chitobiosyldiphosphodolichol beta-mannosyltransferase Neighboring gene DNA polymerase epsilon subunit 3 Neighboring gene Dynein light chain 1, cytoplasmic

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pharyngeal pumping rate does not reflect lifespan extension in C. elegans transgenerational longevity mutants. Croft JC, et al. MicroPubl Biol, 2023. PMID 36793895, Free PMC Article
  2. Repressive H3K9me2 protects lifespan against the transgenerational burden of COMPASS activity in C. elegans. Lee TW, et al. Elife, 2019 Dec 9. PMID 31815663, Free PMC Article
  3. The H3K27 demethylase UTX-1 regulates C. elegans lifespan in a germline-independent, insulin-dependent manner. Maures TJ, et al. Aging Cell, 2011 Dec. PMID 21834846, Free PMC Article
  4. An aging program at the systems level? Han JD. Birth Defects Res C Embryo Today, 2012 Jun. PMID 22692892
  5. Misexpression of the Caenorhabditis elegans miRNA let-7 is sufficient to drive developmental programs. Hayes GD, et al. Cold Spring Harb Symp Quant Biol, 2006. PMID 17381276

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K36me/H3K36me2 demethylase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone demethylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
JmjC domain-containing histone demethylation protein 1
NP_001299886.1
  • Confirmed by transcript evidence
NP_498418.3
  • Confirmed by transcript evidence
NP_498419.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    6454483..6460014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066017.9 → NP_498418.3  JmjC domain-containing histone demethylation protein 1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95Q98, Q95Q99
    Conserved Domains (2) summary
    PHA03193
    Location:1051 → 1102
    PHA03193; tegument protein VP11/12; Provisional
    cl21464
    Location:222 → 321
    cupin_like; Conserved domain found in cupin and related proteins

  2. NM_066018.10 → NP_498419.3  JmjC domain-containing histone demethylation protein 1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95Q98
    Conserved Domains (1) summary
    cl21464
    Location:222 → 321
    cupin_like; Conserved domain found in cupin and related proteins

  3. NM_001312957.3 → NP_001299886.1  JmjC domain-containing histone demethylation protein 1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AUW2
    Conserved Domains (1) summary
    PHA03193
    Location:465 → 516
    PHA03193; tegument protein VP11/12; Provisional
Nucleotide Protein
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