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algn-1 Chitobiosyldiphosphodolichol beta-mannosyltransferase [ Caenorhabditis elegans ]

Gene ID: 175920, updated on 2-Nov-2024

Summary

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Official Symbol
algn-1
Official Full Name
Chitobiosyldiphosphodolichol beta-mannosyltransferase
Primary source
WormBase:WBGene00020820
Locus tag
CELE_T26A5.4
See related
AllianceGenome:WB:WBGene00020820
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable mannosyltransferase activity. Predicted to be involved in protein glycosylation. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ik. Orthologous to several human genes including ALG1 (ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See algn-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
6
Sequence:
Chromosome: III; NC_003281.10 (6460120..6462222)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Histone-lysine N-methyltransferase set-1;SET domain-containing protein Neighboring gene ncRNA Neighboring gene JmjC domain-containing histone demethylation protein 1 Neighboring gene DNA polymerase epsilon subunit 3 Neighboring gene Dynein light chain 1, cytoplasmic Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RNAi screening of human glycogene orthologs in the nematode Caenorhabditis elegans and the construction of the C. elegans glycogene database. Akiyoshi S, et al. Glycobiology, 2015 Jan. PMID 25091817, Free PMC Article
  2. Carbohydrates and glycosylation. Berninsone PM. WormBook, 2006 Dec 18. PMID 18050430, Free PMC Article
  3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mannosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Chitobiosyldiphosphodolichol beta-mannosyltransferase
NP_498420.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    6460120..6462222
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066019.9 → NP_498420.2  Chitobiosyldiphosphodolichol beta-mannosyltransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498420.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q22797
    Conserved Domains (1) summary
    cl10013
    Location:12 → 444
    Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology
Nucleotide Protein
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