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dig-1 Mesocentin [ Caenorhabditis elegans ]

Gene ID: 175951, updated on 2-Nov-2024

Summary

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Official Symbol
dig-1
Official Full Name
Mesocentin
Primary source
WormBase:WBGene00000998
Locus tag
CELE_K07E12.1
See related
AllianceGenome:WB:WBGene00000998
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable calcium ion binding activity. Is expressed in several structures, including GLR; body wall musculature; head mesodermal cell; male sex myoblast; and non-striated muscle. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dig-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
48
Sequence:
Chromosome: III; NC_003281.10 (6746308..6794764)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene F-box domain-containing protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DIG-1, a novel giant protein, non-autonomously mediates maintenance of nervous system architecture. Bénard CY, et al. Development, 2006 Sep. PMID 16887823
  2. The C. elegans gene dig-1 encodes a giant member of the immunoglobulin superfamily that promotes fasciculation of neuronal processes. Burket CT, et al. Dev Biol, 2006 Nov 1. PMID 16928366
  3. Loss of the Extracellular Matrix Protein DIG-1 Causes Glial Fragmentation, Dendrite Breakage, and Dendrite Extension Defects. Chong MK, et al. J Dev Biol, 2021 Oct 7. PMID 34698211, Free PMC Article
  4. Logic programming to predict cell fate patterns and retrodict genotypes in organogenesis. Hall BA, et al. J R Soc Interface, 2014 Sep 6. PMID 24966232, Free PMC Article
  5. Cell interactions coordinate the development of the C. elegans egg-laying system. Thomas JH, et al. Cell, 1990 Sep 21. PMID 2401010

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DIG-1 functions post-developmentally to maintain axons and cell bodies in place within axonal fascicles and ganglia.
    Title: DIG-1, a novel giant protein, non-autonomously mediates maintenance of nervous system architecture.
  2. Mutant phenotypes suggest that DIG-1 may mediate cell movement as well as process fasciculation and that different regions of the protein may mediate these functions.
    Title: The C. elegans gene dig-1 encodes a giant member of the immunoglobulin superfamily that promotes fasciculation of neuronal processes.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mesocentin
NP_001366805.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    6746308..6794764
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001379776.1 → NP_001366805.1  Mesocentin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09165, Q8MTB9
    UniProtKB/TrEMBL
    A0A679L8M9
    Conserved Domains (12) summary
    smart00060
    Location:394 → 478
    FN3; Fibronectin type 3 domain
    smart00179
    Location:12972 → 13013
    EGF_CA; Calcium-binding EGF-like domain
    smart00327
    Location:12151 → 12302
    VWA; von Willebrand factor (vWF) type A domain
    COG1520
    Location:11141 → 11487
    PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]
    cd00063
    Location:993 → 1089
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd01450
    Location:12363 → 12522
    vWFA_subfamily_ECM; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam00047
    Location:1824 → 1903
    ig; Immunoglobulin domain
    pfam13927
    Location:1202 → 1268
    Ig_3; Immunoglobulin domain
    pfam14670
    Location:226 → 262
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cd00096
    Location:1828 → 1831
    Ig; Ig strand A' [structural motif]
    cl00057
    Location:6583 → 6690
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    cl11960
    Location:497 → 578
    Ig; Immunoglobulin domain
Nucleotide Protein
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