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ten-1 EGF-like domain-containing protein;Teneurin-1;Tox-GHH domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 175953, updated on 2-Nov-2024

Summary

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Official Symbol
ten-1
Official Full Name
EGF-like domain-containing protein;Teneurin-1;Tox-GHH domain-containing protein
Primary source
WormBase:WBGene00006498
Locus tag
CELE_R13F6.4
See related
AllianceGenome:WB:WBGene00006498
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in several processes, including axon development; basement membrane assembly involved in embryonic body morphogenesis; and gonad development. Located in nucleus and plasma membrane. Is expressed in several structures, including body muscle cell; epithelial cell; gonad; hypodermis; and nervous system. Human ortholog(s) of this gene implicated in cocaine dependence and essential tremor 5. Orthologous to several human genes including TENM2 (teneurin transmembrane protein 2) and TENM3 (teneurin transmembrane protein 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ten-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
20
Sequence:
Chromosome: III; NC_003281.10 (6820935..6847283)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Palmitoyltransferase Neighboring gene Serpentine receptor class V-1 Neighboring gene Mitogen-activated protein kinase kinase kinase zak-1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Teneurins: Domain Architecture, Evolutionary Origins, and Patterns of Expression. Tucker RP. Front Neurosci, 2018. PMID 30618567, Free PMC Article
  2. Ancient Function of Teneurins in Tissue Organization and Neuronal Guidance in the Nematode Caenorhabditis elegans. Topf U, et al. Front Neurosci, 2019. PMID 30906249, Free PMC Article
  3. Phylogenetic analysis of the teneurins: conserved features and premetazoan ancestry. Tucker RP, et al. Mol Biol Evol, 2012 Mar. PMID 22045996, Free PMC Article
  4. ten-1, an essential gene for germ cell development, epidermal morphogenesis, gonad migration, and neuronal pathfinding in Caenorhabditis elegans. Drabikowski K, et al. Dev Biol, 2005 Jun 1. PMID 15936327
  5. The GPS motif is a molecular switch for bimodal activities of adhesion class G protein-coupled receptors. Prömel S, et al. Cell Rep, 2012 Aug 30. PMID 22938866, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genetic interaction between Caenorhabditis elegans teneurin ten-1 and prolyl 4-hydroxylase phy-1 and their function in collagen IV-mediated basement membrane integrity during late elongation of the embryo
    Title: Genetic interaction between Caenorhabditis elegans teneurin ten-1 and prolyl 4-hydroxylase phy-1 and their function in collagen IV-mediated basement membrane integrity during late elongation of the embryo.
  2. Results are consistent with ten-1 normally providing a function complementary to the cytoskeletal remodeling processes that occur in migrating cells or cells undergoing morphogenesis.
    Title: C. elegans ten-1 is synthetic lethal with mutations in cytoskeleton regulators, and enhances many axon guidance defective mutants.
  3. ten-1 is required for gonadal and pharyngeal basement membrane integrity and acts redundantly with integrin ina-1 and dystroglycan dgn-1
    Title: Caenorhabditis elegans teneurin, ten-1, is required for gonadal and pharyngeal basement membrane integrity and acts redundantly with integrin ina-1 and dystroglycan dgn-1.
  4. Ten-1 acts as a receptor for morphogenetic cue(s) and directly signals to the nucleus by translocation of its intracellular domain to the nucleus following its proteolytic release from the cell membrane.
    Title: ten-1, an essential gene for germ cell development, epidermal morphogenesis, gonad migration, and neuronal pathfinding in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in animal organ morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axonal fasciculation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in basement membrane assembly involved in embryonic body morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in basement membrane organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defecation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic body morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in female gonad development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gamete generation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gonad development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in inductive cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male gonad development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in motor neuron axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in motor neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode pharynx development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in post-embryonic body morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sexual reproduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sexual reproduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
EGF-like domain-containing protein;Teneurin-1;Tox-GHH domain-containing protein
NP_001022723.2
  • Confirmed by transcript evidence
NP_001254940.1
  • Partially confirmed by transcript evidence
NP_001254941.1
  • Partially confirmed by transcript evidence
NP_001379903.1
  • Confirmed by transcript evidence
NP_498487.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    6820935..6847283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001268011.3 → NP_001254940.1  EGF-like domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254940.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H1ZUX0
    Conserved Domains (5) summary
    cd05819
    Location:1335 → 1372
    NHL; NHL repeat [structural motif]
    pfam07974
    Location:662 → 686
    EGF_2; EGF-like domain
    pfam12785
    Location:792 → 896
    VESA1_N; Variant erythrocyte surface antigen-1
    pfam15636
    Location:2763 → 2835
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:1305 → 1663
    NHL; NHL repeat unit of beta-propeller proteins

  2. NM_001268012.3 → NP_001254941.1  EGF-like domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254941.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H1ZUX1
    Conserved Domains (5) summary
    cd05819
    Location:1261 → 1298
    NHL; NHL repeat [structural motif]
    pfam07974
    Location:588 → 612
    EGF_2; EGF-like domain
    pfam12785
    Location:718 → 822
    VESA1_N; Variant erythrocyte surface antigen-1
    pfam15636
    Location:2689 → 2761
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:1231 → 1589
    NHL; NHL repeat unit of beta-propeller proteins

  3. NM_001027552.5 → NP_001022723.2  Teneurin-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022723.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B5BM17, G5EGQ6, Q5CCJ6
    Conserved Domains (5) summary
    cd05819
    Location:1182 → 1219
    NHL; NHL repeat [structural motif]
    pfam07974
    Location:509 → 533
    EGF_2; EGF-like domain
    pfam12785
    Location:639 → 743
    VESA1_N; Variant erythrocyte surface antigen-1
    pfam15636
    Location:2610 → 2682
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:1152 → 1510
    NHL; NHL repeat unit of beta-propeller proteins

  4. NM_001392130.1 → NP_001379903.1  Teneurin-1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (6) summary
    cd05819
    Location:1000 → 1037
    NHL; NHL repeat [structural motif]
    cl18310
    Location:970 → 1328
    NHL; NHL repeat unit of beta-propeller proteins
    pfam00053
    Location:262 → 313
    Laminin_EGF; Laminin EGF domain
    pfam15636
    Location:2428 → 2500
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033662
    Location:578 → 595
    acid_disulf_rpt; acidic double-disulfide repeat
    cl19567
    Location:306 → 351
    DSL; Delta serrate ligand

  5. NM_066086.8 → NP_498487.2  Tox-GHH domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498487.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8I7J1
    Conserved Domains (1) summary
    pfam15636
    Location:815 → 853
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EGQ6.1

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