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cra-1 N-terminal acetyltransferase B complex subunit NAA25 homolog [ Caenorhabditis elegans ]

Gene ID: 175956, updated on 2-Nov-2024

Summary

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Official Symbol
cra-1
Official Full Name
N-terminal acetyltransferase B complex subunit NAA25 homolog
Primary source
WormBase:WBGene00020068
Locus tag
CELE_R13F6.10
See related
AllianceGenome:WB:WBGene00020068
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable acetyltransferase activator activity. Predicted to be involved in cytoskeleton organization. Predicted to be located in chromosome and nucleus. Predicted to be part of NatB complex. Predicted to be active in cytoplasm. Is expressed in body wall musculature; intestine; and reproductive system. Orthologous to human NAA25 (N-alpha-acetyltransferase 25, NatB auxiliary subunit). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cra-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
20
Sequence:
Chromosome: III; NC_003281.10 (6865206..6869460, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Dwarfin sma-3 Neighboring gene KNL (kinetochore null) Binding Protein Neighboring gene Uncharacterized protein Neighboring gene Nucleoporin;Nucleoporin NUP35

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. N-terminal acetylation promotes synaptonemal complex assembly in C. elegans. Gao J, et al. Genes Dev, 2016 Nov 1. PMID 27881602, Free PMC Article
  2. Leptotene/zygotene chromosome movement via the SUN/KASH protein bridge in Caenorhabditis elegans. Baudrimont A, et al. PLoS Genet, 2010 Nov 24. PMID 21124819, Free PMC Article
  3. CRA-1 uncovers a double-strand break-dependent pathway promoting the assembly of central region proteins on chromosome axes during C. elegans meiosis. Smolikov S, et al. PLoS Genet, 2008 Jun 6. PMID 18535664, Free PMC Article
  4. NatB domain-containing CRA-1 antagonizes hydrolase ACER-1 linking acetyl-CoA metabolism to the initiation of recombination during C. elegans meiosis. Gao J, et al. PLoS Genet, 2015 Mar. PMID 25768301, Free PMC Article
  5. Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans. Gottschalk A, et al. EMBO J, 2005 Jul 20. PMID 15990870, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables acetyltransferase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of NatB complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
N-terminal acetyltransferase B complex subunit NAA25 homolog
NP_498494.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    6865206..6869460 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066093.7 → NP_498494.2  N-terminal acetyltransferase B complex subunit NAA25 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498494.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q21986
    Conserved Domains (3) summary
    sd00006
    Location:42 → 71
    TPR; TPR repeat [structural motif]
    pfam09797
    Location:261 → 641
    NatB_MDM20; N-acetyltransferase B complex (NatB) non catalytic subunit
    pfam14559
    Location:20 → 83
    TPR_19; Tetratricopeptide repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q21986.3

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