pdf-1 Pigment dispersing factor homolog pdf-1 [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: pdf-1
Official Full Name: Pigment dispersing factor homolog pdf-1
Primary source: WormBase:WBGene00020317
Locus tag: CELE_T07E3.6
See related: AllianceGenome:WB:WBGene00020317
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in several processes, including locomotion involved in locomotory behavior; locomotor rhythm; and locomotory exploration behavior. Predicted to be located in extracellular region. Is expressed in neurons and rectum. [provided by Alliance of Genome Resources, Nov 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See pdf-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 4

Sequence:: Chromosome: III; NC_003281.10 (6909590..6912266, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In Drosophila, the ion channel narrow abdomen, an ortholog of the C. elegans NCA channels, drive the pigment dispersing factor (PDF) neuropeptide release, regulating circadian behavior. However, in C. elegans, we found that loss of the PDF receptor PDFR-1 did not suppress gain-of-function sleep defects, suggesting an alternative downstream pathway.
Title: Gap Junctions and NCA Cation Channels Are Critical for Developmentally Timed Sleep and Arousal in Caenorhabditis elegans.
PDF-1 signaling acts sex- and cell-specifically in the ASJ neurons to regulate the expression of daf-7.
Title: PDF-1 neuropeptide signaling regulates sexually dimorphic gene expression in shared sensory neurons of C. elegans.
we have studied the role of the PDF neuropeptide in the circadian system of C. elegans
Title: Pigment-dispersing factor signaling in the circadian system of Caenorhabditis elegans.
Pigment dispersing factor receptor (PDFR)-1 and its ligand PDF-1 stimulate mate searching in the male, but not in the hermaphrodite.
Title: PDF-1 neuropeptide signaling modulates a neural circuit for mate-searching behavior in C. elegans.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

T07E3.6 (e-PCR)
- UniSTS:322309

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotion involved in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotory exploration behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male mating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in parturition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein secretion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sleep	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sleep	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: Pigment dispersing factor homolog pdf-1

NP_001379990.1

Confirmed by transcript evidence

NP_741206.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

6909590..6912266 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_171878.7 → NP_741206.2 Pigment dispersing factor homolog pdf-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

B2BBX9, G5EEV3, G8JYC6, Q8WQD1
NM_001392134.1 → NP_001379990.1 Pigment dispersing factor homolog pdf-1 [Caenorhabditis elegans]

Status: REVIEWED