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flap-1 Leucine-rich repeat flightless-interacting protein 2 [ Caenorhabditis elegans ]

Gene ID: 175964, updated on 2-Nov-2024

Summary

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Official Symbol
flap-1
Official Full Name
Leucine-rich repeat flightless-interacting protein 2
Primary source
WormBase:WBGene00018998
Locus tag
CELE_F57B9.7
See related
AllianceGenome:WB:WBGene00018998
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in regulation of DNA-templated transcription. Orthologous to several human genes including LRRFIP2 (LRR binding FLII interacting protein 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See flap-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
10
Sequence:
Chromosome: III; NC_003281.10 (6923971..6928825, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Pigment dispersing factor homolog pdf-1 Neighboring gene ncRNA Neighboring gene Eukaryotic initiation factor 4A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. F-actin asymmetry and the endoplasmic reticulum-associated TCC-1 protein contribute to stereotypic spindle movements in the Caenorhabditis elegans embryo. Berends CW, et al. Mol Biol Cell, 2013 Jul. PMID 23699393, Free PMC Article
  2. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
  3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Leucine-rich repeat flightless-interacting protein 2
NP_741207.1
  • Confirmed by transcript evidence
NP_741208.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    6923971..6928825 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171178.7 → NP_741207.1  Leucine-rich repeat flightless-interacting protein 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741207.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KZX2
    Conserved Domains (1) summary
    pfam09738
    Location:59 → 280
    DUF2051; Double stranded RNA binding protein (DUF2051)

  2. NM_171879.7 → NP_741208.1  Leucine-rich repeat flightless-interacting protein 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741208.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MQ17
    Conserved Domains (1) summary
    pfam09738
    Location:30 → 300
    DUF2051; Double stranded RNA binding protein (DUF2051)
Nucleotide Protein
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