coq-2 4-hydroxybenzoate polyprenyltransferase, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: coq-2
Official Full Name: 4-hydroxybenzoate polyprenyltransferase, mitochondrial
Primary source: WormBase:WBGene00000762
Locus tag: CELE_F57B9.4
See related: AllianceGenome:WB:WBGene00000762
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable 4-hydroxybenzoate polyprenyltransferase activity. Involved in ubiquinone biosynthetic process. Predicted to be located in mitochondrial membrane. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 1. Orthologous to human COQ2 (coenzyme Q2, polyprenyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See coq-2 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 9

Sequence:: Chromosome: III; NC_003281.10 (6935967..6939457)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Alternative splicing of coq-2 controls the levels of rhodoquinone in animals.
Title: Alternative splicing of coq-2 controls the levels of rhodoquinone in animals.

Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

F57B9.4 (e-PCR)
- UniSTS:319428

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 4-hydroxybenzoate polyprenyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 4-hydroxybenzoate polyprenyltransferase activity	IEA Inferred from Electronic Annotation more info
enables polyprenyltransferase activity	IEA Inferred from Electronic Annotation more info
enables prenyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity, transferring alkyl or aryl (other than methyl) groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in isoprenoid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquinone biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquinone biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquinone biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 4-hydroxybenzoate polyprenyltransferase, mitochondrial

NP_498513.2

Confirmed by transcript evidence

NP_871684.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

6935967..6939457

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_181955.5 → NP_871684.1 4-hydroxybenzoate polyprenyltransferase, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_871684.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q5DX46, Q8I7J4

Conserved Domains (1) summary

cl00337
Location:59 → 343

PT_UbiA; UbiA family of prenyltransferases (PTases)
NM_066112.7 → NP_498513.2 4-hydroxybenzoate polyprenyltransferase, mitochondrial [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q5DX46, Q8I7J4

Conserved Domains (1) summary

cl00337
Location:59 → 343

PT_UbiA; UbiA family of prenyltransferases (PTases)