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let-711 CCR4-NOT transcription complex subunit let-711 [ Caenorhabditis elegans ]

Gene ID: 175971, updated on 2-Nov-2024

Summary

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Official Symbol
let-711
Official Full Name
CCR4-NOT transcription complex subunit let-711
Primary source
WormBase:WBGene00002845
Locus tag
CELE_F57B9.2
See related
AllianceGenome:WB:WBGene00002845
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable molecular adaptor activity. Involved in several processes, including microtubule cytoskeleton organization; nematode larval development; and post-transcriptional regulation of gene expression. Located in cytoplasm. Part of CCR4-NOT complex. Is expressed in germ line; gonad; and in male. Human ortholog(s) of this gene implicated in Vissers-Bodmer syndrome and holoprosencephaly 12. Orthologous to human CNOT1 (CCR4-NOT transcription complex subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See let-711 in Genome Data Viewer
Location:
chromosome: III
Exon count:
18
Sequence:
Chromosome: III; NC_003281.10 (6946718..6958894)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene RNA helicase Neighboring gene Activated in Blocked Unfolded protein response Neighboring gene ncRNA Neighboring gene putative 26S proteasome regulatory subunit rpn-6.1 Neighboring gene Putative pyridoxamine 5'-phosphate oxidase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. LET-711, the Caenorhabditis elegans NOT1 ortholog, is required for spindle positioning and regulation of microtubule length in embryos. DeBella LR, et al. Mol Biol Cell, 2006 Nov. PMID 16971515, Free PMC Article
  2. A continuum of mRNP complexes in embryonic microRNA-mediated silencing. Wu E, et al. Nucleic Acids Res, 2017 Feb 28. PMID 28204614, Free PMC Article
  3. The let-99 gene is required for proper spindle orientation during cleavage of the C. elegans embryo. Rose LS, et al. Development, 1998 Apr. PMID 9477332
  4. Lethal mutations defining 112 complementation groups in a 4.5 Mb sequenced region of Caenorhabditis elegans chromosome III. Stewart HI, et al. Mol Gen Genet, 1998 Nov. PMID 9862482
  5. The in vivo functional significance of PUF hub partnerships in C. elegans germline stem cells. Ferdous AS, et al. Development, 2023 May 1. PMID 37070766, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. let-711 is required for spindle positioning in the early embryo
    Title: LET-711, the Caenorhabditis elegans NOT1 ortholog, is required for spindle positioning and regulation of microtubule length in embryos.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in astral microtubule organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of mitotic spindle localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear-transcribed mRNA poly(A) tail shortening IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulatory ncRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of CCR4-NOT complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of CCR4-NOT core complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CCR4-NOT core complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CCR4-NOT transcription complex subunit let-711
NP_001333557.1
  • Confirmed by transcript evidence
NP_001333558.1
  • Confirmed by transcript evidence
NP_001333559.1
  • Confirmed by transcript evidence
NP_001368611.1
  • Confirmed by transcript evidence
NP_498516.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    6946718..6958894
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066115.6 → NP_498516.3  CCR4-NOT transcription complex subunit let-711 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498516.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A1D3PCL8, A0A1D3PCL9, A0A1D3PCM5, Q20937, S5ZDJ9
    Conserved Domains (4) summary
    PHA03378
    Location:832 → 990
    PHA03378; EBNA-3B; Provisional
    COG5103
    Location:1035 → 2602
    CDC39; Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]
    pfam04054
    Location:2235 → 2599
    Not1; CCR4-Not complex component, Not1
    pfam16418
    Location:592 → 743
    CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat

  2. NM_001379782.1 → NP_001368611.1  CCR4-NOT transcription complex subunit let-711 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (4) summary
    PHA03378
    Location:815 → 973
    PHA03378; EBNA-3B; Provisional
    COG5103
    Location:1018 → 2585
    CDC39; Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]
    pfam04054
    Location:2218 → 2582
    Not1; CCR4-Not complex component, Not1
    pfam16418
    Location:575 → 726
    CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat

  3. NM_001346615.3 → NP_001333557.1  CCR4-NOT transcription complex subunit let-711 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1D3PCL8
    Conserved Domains (4) summary
    PHA03378
    Location:525 → 683
    PHA03378; EBNA-3B; Provisional
    COG5103
    Location:728 → 2295
    CDC39; Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]
    pfam04054
    Location:1935 → 2292
    Not1; CCR4-Not complex component, Not1
    pfam16418
    Location:285 → 436
    CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat

  4. NM_001346616.3 → NP_001333558.1  CCR4-NOT transcription complex subunit let-711 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    S5ZDJ9
    Conserved Domains (3) summary
    PHA03378
    Location:66 → 197
    PHA03378; EBNA-3B; Provisional
    COG5103
    Location:269 → 1836
    CDC39; Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]
    pfam04054
    Location:1476 → 1833
    Not1; CCR4-Not complex component, Not1

  5. NM_001346617.3 → NP_001333559.1  CCR4-NOT transcription complex subunit let-711 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1D3PCL9
    Conserved Domains (1) summary
    pfam04054
    Location:1 → 215
    Not1; CCR4-Not complex component, Not1
Nucleotide Protein
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