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eef-1A.1 Elongation factor 1-alpha [ Caenorhabditis elegans ]

Gene ID: 175975, updated on 2-Nov-2024

Summary

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Official Symbol
eef-1A.1
Official Full Name
Elongation factor 1-alpha
Primary source
WormBase:WBGene00001168
Locus tag
CELE_F31E3.5
See related
AllianceGenome:WB:WBGene00001168
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables GTPase activity. Predicted to be involved in translational elongation. Predicted to be located in cytoplasm. Is expressed in several structures, including body wall musculature; hypodermis; intestine; muscle cell; and pharynx. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 38; developmental and epileptic encephalopathy 33; and ovarian cancer. Orthologous to human EEF1A1 (eukaryotic translation elongation factor 1 alpha 1); EEF1A1P5 (eukaryotic translation elongation factor 1 alpha 1 pseudogene 5); and EEF1A2 (eukaryotic translation elongation factor 1 alpha 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See eef-1A.1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (6970026..6971712, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Replication factor C subunit 4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Efficient generation of a single-copy eft-3p::TIR1::F2A:: BFP::AID*::NLS allele in the C. elegans ttTi5605 insertion site through recombination-mediated cassette exchange. Vo AA, et al. MicroPubl Biol, 2021. PMID 34355140, Free PMC Article
  2. Mechanisms of EF-Tu, a pioneer GTPase. Krab IM, et al. Prog Nucleic Acid Res Mol Biol, 2002. PMID 12102560
  3. Identifying interacting proteins of a Caenorhabditis elegans voltage-gated chloride channel CLH-1 using GFP-Trap and mass spectrometry. Zhou ZL, et al. Sheng Li Xue Bao, 2014 Jun 25. PMID 24964852
  4. The killifish germline regulates longevity and somatic repair in a sex-specific manner. Moses E, et al. Nat Aging, 2024 Jun. PMID 38750187
  5. 5'-Modifications improve potency and efficacy of DNA donors for precision genome editing. Ghanta KS, et al. Elife, 2021 Oct 19. PMID 34665130, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation elongation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables translation factor activity, RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational elongation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Elongation factor 1-alpha
NP_498520.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    6970026..6971712 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066119.9 → NP_498520.1  Elongation factor 1-alpha [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498520.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P53013
    Conserved Domains (4) summary
    PTZ00141
    Location:1 → 461
    PTZ00141; elongation factor 1- alpha; Provisional
    cd01883
    Location:9 → 239
    EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
    cd03693
    Location:242 → 332
    EF1_alpha_II; Domain II of elongation factor 1-alpha
    cd03705
    Location:335 → 438
    EF1_alpha_III; Domain III of Elongation Factor 1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53013.1

Gene LinkOut

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