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cyk-1 WAPL domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 175983, updated on 2-Nov-2024

Summary

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Official Symbol
cyk-1
Official Full Name
WAPL domain-containing protein
Primary source
WormBase:WBGene00000872
Locus tag
CELE_F11H8.4
See related
AllianceGenome:WB:WBGene00000872
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable actin binding activity and small GTPase binding activity. Involved in pronuclear migration. Located in actomyosin contractile ring; cleavage furrow; and cytoplasmic side of plasma membrane. Is expressed in body wall musculature; excretory cell; and germ line. Human ortholog(s) of this gene implicated in autosomal dominant auditory neuropathy 1; autosomal dominant nonsyndromic deafness 1; primary ovarian insufficiency; primary ovarian insufficiency 2A; and sensorineural hearing loss. Orthologous to several human genes including DIAPH1 (diaphanous related formin 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cyk-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
14
Sequence:
Chromosome: III; NC_003281.10 (7023642..7029205, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Gamma-aminobutyric acid receptor subunit beta Neighboring gene Cuticle collagen 8 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene NEDD8-activating enzyme E1 catalytic subunit Neighboring gene tRNA-Thr Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The ARP2/3 complex prevents excessive formin activity during cytokinesis. Chan FY, et al. Mol Biol Cell, 2019 Jan 1. PMID 30403552, Free PMC Article
  2. Septins and a formin have distinct functions in anaphase chiral cortical rotation in the Caenorhabditis elegans zygote. Zaatri A, et al. Mol Biol Cell, 2021 Jul 1. PMID 34010018, Free PMC Article
  3. Filament-guided filament assembly provides structural memory of filament alignment during cytokinesis. Li Y, et al. Dev Cell, 2021 Sep 13. PMID 34480876, Free PMC Article
  4. Syncytial germline architecture is actively maintained by contraction of an internal actomyosin corset. Priti A, et al. Nat Commun, 2018 Nov 8. PMID 30410005, Free PMC Article
  5. The cytokinesis formins from the nematode worm and fission yeast differentially mediate actin filament assembly. Neidt EM, et al. J Biol Chem, 2008 Aug 29. PMID 18577519, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CYK-1/Formin activation in cortical RhoA signaling centers promotes organismal left-right symmetry breaking.
    Title: CYK-1/Formin activation in cortical RhoA signaling centers promotes organismal left-right symmetry breaking.
  2. the ARP2/3 complex negatively regulates CYK-1 activity.
    Title: The ARP2/3 complex prevents excessive formin activity during cytokinesis.
  3. PTRN-1 CH domain is required to stimulate CYK-1 to facilitate actin dynamics during endocytic recycling.
    Title: PTRN-1/CAMSAP promotes CYK-1/formin-dependent actin polymerization during endocytic recycling.
  4. Both Cdc12p and CYK-1 bind to pre-assembled actin filaments with low nanomolar affinity, but CYK-1 dissociates 2 orders of magnitude more quickly.
    Title: The cytokinesis formins from the nematode worm and fission yeast differentially mediate actin filament assembly.
  5. protein CYK-1 and the profilin PFN-1 mediate the Arp2/3-independent assembly of cortical microfilaments and are required for cytokinesis in the early embryo
    Title: A Formin Homology protein and a profilin are required for cytokinesis and Arp2/3-independent assembly of cortical microfilaments in C. elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular component organization IEA
Inferred from Electronic Annotation
more info
  
involved_in pronuclear migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actomyosin contractile ring IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cleavage furrow IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
WAPL domain-containing protein
NP_741210.3
  • Confirmed by transcript evidence
NP_741211.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    7023642..7029205 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171880.6 → NP_741211.3  WAPL domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741211.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JP75
    Conserved Domains (3) summary
    smart00498
    Location:807 → 1257
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:422 → 630
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:201 → 387
    Drf_GBD; Diaphanous GTPase-binding Domain

  2. NM_171180.5 → NP_741210.3  WAPL domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741210.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KYI3
    Conserved Domains (3) summary
    smart00498
    Location:807 → 1257
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:422 → 630
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:201 → 387
    Drf_GBD; Diaphanous GTPase-binding Domain
Nucleotide Protein
Heading Accession and Version

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