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tofu-7 K Homology domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 175988, updated on 2-Nov-2024

Summary

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Official Symbol
tofu-7
Official Full Name
K Homology domain-containing protein
Primary source
WormBase:WBGene00022737
Locus tag
CELE_ZK418.8
See related
AllianceGenome:WB:WBGene00022737
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in mRNA processing and regulation of alternative mRNA splicing, via spliceosome. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tofu-7 in Genome Data Viewer
Location:
chromosome: III
Exon count:
6
Sequence:
Chromosome: III; NC_003281.10 (7083684..7085018, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA Neighboring gene K Homology domain-containing protein Neighboring gene NR LBD domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A genome-wide RNAi screen identifies factors required for distinct stages of C. elegans piRNA biogenesis. Goh WS, et al. Genes Dev, 2014 Apr 1. PMID 24696458, Free PMC Article
  2. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
  3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tofu-7 is required for the biogenesis of 21U-RNAs.
    Title: A genome-wide RNAi screen identifies factors required for distinct stages of C. elegans piRNA biogenesis.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
K Homology domain-containing protein
NP_498547.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    7083684..7085018 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066146.8 → NP_498547.1  K Homology domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498547.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q23486
    Conserved Domains (2) summary
    smart00322
    Location:59 → 110
    KH; K homology RNA-binding domain
    pfam00013
    Location:165 → 216
    KH_1; KH domain
Nucleotide Protein
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