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pfd-5 putative prefoldin subunit 5 [ Caenorhabditis elegans ]

Gene ID: 176013, updated on 2-Nov-2024

Summary

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Official Symbol
pfd-5
Official Full Name
putative prefoldin subunit 5
Primary source
WormBase:WBGene00020112
Locus tag
CELE_R151.9
See related
AllianceGenome:WB:WBGene00020112
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable unfolded protein binding activity. Predicted to be involved in RNA polymerase I assembly; RNA polymerase II core complex assembly; and RNA polymerase III assembly. Predicted to be part of prefoldin complex. Predicted to be active in cytoplasm. Is expressed in body wall musculature; pharyngeal muscle cell; and vulval muscle. Orthologous to human PFDN5 (prefoldin subunit 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pfd-5 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (7198151..7198884, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene CDT1 domain-containing protein Neighboring gene Exosome complex component RRP45 Neighboring gene ncRNA Neighboring gene Zinc metalloproteinase dpy-31 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Efficient chaperone-mediated tubulin biogenesis is essential for cell division and cell migration in C. elegans. Lundin VF, et al. Dev Biol, 2008 Jan 1. PMID 18062952
  2. Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C. elegans. Son HG, et al. Genes Dev, 2018 Dec 1. PMID 30478249, Free PMC Article
  3. The nascent polypeptide-associated complex is a key regulator of proteostasis. Kirstein-Miles J, et al. EMBO J, 2013 May 15. PMID 23604074, Free PMC Article
  4. Gamma radiation induces life stage-dependent reprotoxicity in Caenorhabditis elegans via impairment of spermatogenesis. Maremonti E, et al. Sci Total Environ, 2019 Dec 10. PMID 31425988
  5. A global analysis of genetic interactions in Caenorhabditis elegans. Byrne AB, et al. J Biol, 2007. PMID 17897480, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase I assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA polymerase II core complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA polymerase III assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of prefoldin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of prefoldin complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative prefoldin subunit 5
NP_498582.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    7198151..7198884 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066181.6 → NP_498582.1  putative prefoldin subunit 5 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498582.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q21993
    Conserved Domains (1) summary
    TIGR00293
    Location:15 → 141
    TIGR00293; prefoldin, archaeal alpha subunit/eukaryotic subunit 5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q21993.1

Gene LinkOut

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