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dpy-31 Zinc metalloproteinase dpy-31 [ Caenorhabditis elegans ]

Gene ID: 176014, updated on 2-Nov-2024

Summary

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Official Symbol
dpy-31
Official Full Name
Zinc metalloproteinase dpy-31
Primary source
WormBase:WBGene00006592
Locus tag
CELE_R151.5
See related
AllianceGenome:WB:WBGene00006592
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metalloendopeptidase activity. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle. Predicted to be located in extracellular region. Is expressed in several structures, including amphid sheath cell; excretory duct; hypodermis; socket cell; and vulva. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dpy-31 in Genome Data Viewer
Location:
chromosome: III
Exon count:
8
Sequence:
Chromosome: III; NC_003281.10 (7202661..7207664)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene putative prefoldin subunit 5 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Large ribosomal subunit protein eL6 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and activity of inhibitors of the essential nematode-specific metalloprotease DPY-31. France DJ, et al. Bioorg Med Chem Lett, 2015 Dec 15. PMID 26546217, Free PMC Article
  2. A highly conserved, inhibitable astacin metalloprotease from Teladorsagia circumcincta is required for cuticle formation and nematode development. Stepek G, et al. Int J Parasitol, 2015 Apr. PMID 25736599, Free PMC Article
  3. Collagen processing and cuticle formation is catalysed by the astacin metalloprotease DPY-31 in free-living and parasitic nematodes. Stepek G, et al. Int J Parasitol, 2010 Apr. PMID 19883650
  4. hch-1, a gene required for normal hatching and normal migration of a neuroblast in C. elegans, encodes a protein related to TOLLOID and BMP-1. Hishida R, et al. EMBO J, 1996 Aug 15. PMID 8861940, Free PMC Article
  5. Gene interactions in Caenorhabditis elegans define DPY-31 as a candidate procollagen C-proteinase and SQT-3/ROL-4 as its predicted major target. Novelli J, et al. Genetics, 2004 Nov. PMID 15579684, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. analysis of the roles of dpy-31, sqt-3, and dpy-17 in nematode collagen assembly
    Title: The C terminus of collagen SQT-3 has complex and essential functions in nematode collagen assembly.
  2. Responsible for C-terminal proteolytic processing of collagen trimers, homolog of vertebrate BMP-1.
    Title: Gene interactions in Caenorhabditis elegans define DPY-31 as a candidate procollagen C-proteinase and SQT-3/ROL-4 as its predicted major target.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cuticle development involved in collagen and cuticulin-based cuticle molting cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in molting cycle, collagen and cuticulin-based cuticle IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Zinc metalloproteinase dpy-31
NP_001022731.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    7202661..7207664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027560.6 → NP_001022731.1  Zinc metalloproteinase dpy-31 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022731.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P98060, Q6AHR4
    Conserved Domains (4) summary
    smart00042
    Location:383 → 483
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    smart00209
    Location:493 → 539
    TSP1; Thrombospondin type 1 repeats
    cd04280
    Location:139 → 324
    ZnMc_astacin_like; Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to ...
    pfam01400
    Location:134 → 327
    Astacin; Astacin (Peptidase family M12A)

RNA

  1. NR_132452.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P98060.2

Gene LinkOut

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