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prps-1 Ribose-phosphate pyrophosphokinase 2 [ Caenorhabditis elegans ]

Gene ID: 176016, updated on 2-Nov-2024

Summary

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Official Symbol
prps-1
Official Full Name
Ribose-phosphate pyrophosphokinase 2
Primary source
WormBase:WBGene00020107
Locus tag
CELE_R151.2
See related
AllianceGenome:WB:WBGene00020107
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ribose phosphate diphosphokinase activity. Predicted to be involved in 5-phosphoribose 1-diphosphate biosynthetic process and purine nucleotide biosynthetic process. Predicted to be part of ribose phosphate diphosphokinase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including intestine; nervous system; reproductive system; somatic gonad precursor; and tail. Human ortholog(s) of this gene implicated in Arts syndrome; X-linked deafness 1; X-linked recessive disease (multiple); gout; and retinitis pigmentosa. Orthologous to human PRPS1 (phosphoribosyl pyrophosphate synthetase 1); PRPS1L1 (phosphoribosyl pyrophosphate synthetase 1 like 1); and PRPS2 (phosphoribosyl pyrophosphate synthetase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See prps-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
9
Sequence:
Chromosome: III; NC_003281.10 (7209967..7215291)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Large ribosomal subunit protein eL6 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. mRNA profiling reveals significant transcriptional differences between a multipotent progenitor and its differentiated sister. Mathies LD, et al. BMC Genomics, 2019 May 28. PMID 31138122, Free PMC Article
  2. FACT Sets a Barrier for Cell Fate Reprogramming in Caenorhabditis elegans and Human Cells. Kolundzic E, et al. Dev Cell, 2018 Sep 10. PMID 30078731, Free PMC Article
  3. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article
  4. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article
  5. A protein domain-based interactome network for C. elegans early embryogenesis. Boxem M, et al. Cell, 2008 Aug 8. PMID 18692475, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ribose phosphate diphosphokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribose phosphate diphosphokinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 5-phosphoribose 1-diphosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 5-phosphoribose 1-diphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in purine nucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribose phosphate diphosphokinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Ribose-phosphate pyrophosphokinase 2
NP_001022728.2
  • Confirmed by transcript evidence
NP_001367827.1
  • Confirmed by transcript evidence
NP_498586.2
  • Partially confirmed by transcript evidence
NP_498587.2
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    7209967..7215291
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027557.8 → NP_001022728.2  Ribose-phosphate pyrophosphokinase 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022728.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6AHR3
    Conserved Domains (1) summary
    COG0462
    Location:128 → 440
    PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]

  2. NM_066185.5 → NP_498586.2  Ribose-phosphate pyrophosphokinase 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498586.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q21994
    Conserved Domains (1) summary
    COG0462
    Location:59 → 371
    PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]

  3. NM_001379786.1 → NP_001367827.1  Ribose-phosphate pyrophosphokinase 2 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9BI73
    Conserved Domains (1) summary
    COG0462
    Location:1 → 313
    PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]

  4. NM_066186.7 → NP_498587.2  Ribose-phosphate pyrophosphokinase 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498587.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95QB6
    Conserved Domains (1) summary
    COG0462
    Location:5 → 312
    PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]
Nucleotide Protein
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