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hsp-75 Histidine kinase/HSP90-like ATPase domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 176019, updated on 2-Nov-2024

Summary

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Official Symbol
hsp-75
Official Full Name
Histidine kinase/HSP90-like ATPase domain-containing protein
Primary source
WormBase:WBGene00020110
Locus tag
CELE_R151.7
See related
AllianceGenome:WB:WBGene00020110
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and unfolded protein binding activity. Predicted to be involved in protein folding. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial inner membrane. Orthologous to human TRAP1 (TNF receptor associated protein 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hsp-75 in Genome Data Viewer
Location:
chromosome: III
Exon count:
9
Sequence:
Chromosome: III; NC_003281.10 (7223233..7226707, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA Neighboring gene Derlin-2 Neighboring gene Myb-like domain-containing protein Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Caenorhabditis elegans mRNAs that encode a protein similar to ADARs derive from an operon containing six genes. Hough RF, et al. Nucleic Acids Res, 1999 Sep 1. PMID 10446229, Free PMC Article
  2. A transmembrane guanylyl cyclase (DAF-11) and Hsp90 (DAF-21) regulate a common set of chemosensory behaviors in caenorhabditis elegans. Birnby DA, et al. Genetics, 2000 May. PMID 10790386, Free PMC Article
  3. Caenorhabditis elegans as a model system to study intercompartmental proteostasis: Interrelation of mitochondrial function, longevity, and neurodegenerative diseases. Kirstein-Miles J, et al. Dev Dyn, 2010 May. PMID 20419784, Free PMC Article
  4. A global analysis of genetic interactions in Caenorhabditis elegans. Byrne AB, et al. J Biol, 2007. PMID 17897480, Free PMC Article
  5. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Histidine kinase/HSP90-like ATPase domain-containing protein
NP_741220.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    7223233..7226707 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171881.6 → NP_741220.2  Histidine kinase/HSP90-like ATPase domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741220.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q2L6Y6
    Conserved Domains (1) summary
    PRK05218
    Location:40 → 662
    PRK05218; heat shock protein 90; Provisional
Nucleotide Protein
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