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hmg-4 FACT complex subunit SSRP1-A [ Caenorhabditis elegans ]

Gene ID: 176052, updated on 2-Nov-2024

Summary

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Official Symbol
hmg-4
Official Full Name
FACT complex subunit SSRP1-A
Primary source
WormBase:WBGene00001974
Locus tag
CELE_T20B12.8
See related
AllianceGenome:WB:WBGene00001974
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable histone binding activity and nucleosome binding activity. Involved in nematode pharynx development and regulation of embryonic development. Located in nucleus. Is expressed in several structures, including germ line; head muscle; neurons; somatic cell; and somatic nervous system. Orthologous to human SSRP1 (structure specific recognition protein 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hmg-4 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (7379143..7381596, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene BHLH domain-containing protein;Protein WBSCR14 homolog Neighboring gene ncRNA Neighboring gene Anamorsin homolog Neighboring gene Uncharacterized protein Neighboring gene TATA-box-binding protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. FACT complex gene duplicates exhibit redundant and non-redundant functions in C. elegans. Suggs BZ, et al. Dev Biol, 2018 Dec 15. PMID 30336114, Free PMC Article
  2. Caudal-like PAL-1 directly activates the bodywall muscle module regulator hlh-1 in C. elegans to initiate the embryonic muscle gene regulatory network. Lei H, et al. Development, 2009 Apr. PMID 19261701, Free PMC Article
  3. Gene expression profiling of epidermal cell types in C. elegans using Targeted DamID. Katsanos D, et al. Development, 2021 Sep 1. PMID 34397094, Free PMC Article
  4. CUL-2(LRR-1) and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis. Sonneville R, et al. Nat Cell Biol, 2017 May. PMID 28368371, Free PMC Article
  5. Transcription factors regulating the fate and developmental potential of a multipotent progenitor in Caenorhabditis elegans. Soukup EM, et al. G3 (Bethesda), 2022 Nov 4. PMID 36063055, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in nematode pharynx development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of chromatin organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of embryonic development IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of FACT complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
FACT complex subunit SSRP1-A
NP_498633.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    7379143..7381596 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066232.7 → NP_498633.1  FACT complex subunit SSRP1-A [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498633.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P41848
    Conserved Domains (3) summary
    cd01390
    Location:556 → 619
    HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...
    cd13231
    Location:332 → 429
    PH2_SSRP1-like; Structure Specific Recognition protein 1 (SSRP1) Pleckstrin homology (PH) domain, repeat 2
    pfam03531
    Location:75 → 285
    SSrecog; Structure-specific recognition protein (SSRP1)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41848.1

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