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alh-12 Aldehyde dehydrogenase domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 176056, updated on 2-Nov-2024

Summary

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Official Symbol
alh-12
Official Full Name
Aldehyde dehydrogenase domain-containing protein
Primary source
WormBase:WBGene00000118
Locus tag
CELE_Y69F12A.2
See related
AllianceGenome:WB:WBGene00000118
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable 4-trimethylammoniobutyraldehyde dehydrogenase activity and aminobutyraldehyde dehydrogenase (NAD+) activity. Orthologous to human ALDH9A1 (aldehyde dehydrogenase 9 family member A1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See alh-12 in Genome Data Viewer
Location:
chromosome: III
Exon count:
3
Sequence:
Chromosome: III; NC_003281.10 (7454074..7455936)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Ligand-gated ion channel 50 Neighboring gene ncRNA Neighboring gene Protein kinase domain-containing protein Neighboring gene FIP (Fungus-Induced Protein) Related

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Targeting Mitochondrial Network Disorganization is Protective in C. elegans Models of Huntington's Disease. Machiela E, et al. Aging Dis, 2021 Oct. PMID 34631219, Free PMC Article
  2. The embryonic muscle transcriptome of Caenorhabditis elegans. Fox RM, et al. Genome Biol, 2007. PMID 17848203, Free PMC Article
  3. Proteomic analysis of protein expression profiles during Caenorhabditis elegans development using two-dimensional difference gel electrophoresis. Tabuse Y, et al. Proteomics, 2005 Jul. PMID 15996007
  4. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
  5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 4-trimethylammoniobutyraldehyde dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aminobutyraldehyde dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Aldehyde dehydrogenase domain-containing protein
NP_001022930.1
  • Confirmed by transcript evidence
NP_001370775.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    7454074..7455936
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001382916.1 → NP_001370775.1  Aldehyde dehydrogenase domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7Z1Q2
    Conserved Domains (1) summary
    cl11961
    Location:31 → 430
    ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily

  2. NM_001027759.4 → NP_001022930.1  Aldehyde dehydrogenase domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022930.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7Z1Q3
    Conserved Domains (1) summary
    cd07090
    Location:31 → 492
    ALDH_F9_TMBADH; NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1
Nucleotide Protein
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