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cls-1 Protein CLASP-1 [ Caenorhabditis elegans ]

Gene ID: 176064, updated on 2-Nov-2024

Summary

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Official Symbol
cls-1
Official Full Name
Protein CLASP-1
Primary source
WormBase:WBGene00015580
Locus tag
CELE_C07H6.3
See related
AllianceGenome:WB:WBGene00015580
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable microtubule binding activity. Involved in microtubule cytoskeleton organization and positive regulation of microtubule depolymerization. Predicted to be located in cytoplasm and microtubule. Predicted to be active in basal cortex; kinetochore; and microtubule cytoskeleton. Is expressed in several structures, including nervous system; pharyngeal-intestinal valve; pharynx; rectal gland cell; and reproductive system. Orthologous to several human genes including CLASP2 (cytoplasmic linker associated protein 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cls-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
16
Sequence:
Chromosome: III; NC_003281.10 (7508178..7515285)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class Z Neighboring gene U2 snRNP-associated SURP motif-containing protein Neighboring gene Telomere length regulation protein clk-2 Neighboring gene RRM domain-containing protein Neighboring gene E3 ubiquitin-protein ligase PPP1R11

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of microtubule dynamics by TOG-domain proteins XMAP215/Dis1 and CLASP. Al-Bassam J, et al. Trends Cell Biol, 2011 Oct. PMID 21782439, Free PMC Article
  2. Chromatids segregate without centrosomes during Caenorhabditis elegans mitosis in a Ran- and CLASP-dependent manner. Nahaboo W, et al. Mol Biol Cell, 2015 Jun 1. PMID 25833711, Free PMC Article
  3. CLASPs function redundantly to regulate astral microtubules in the C. elegans embryo. Espiritu EB, et al. Dev Biol, 2012 Aug 15. PMID 22613359, Free PMC Article
  4. In situ imaging in C. elegans reveals developmental regulation of microtubule dynamics. Lacroix B, et al. Dev Cell, 2014 Apr 28. PMID 24780738, Free PMC Article
  5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in astral microtubule organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of mitotic spindle localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of mitotic spindle localization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of microtubule depolymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of microtubule polymerization or depolymerization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of supramolecular fiber organization IEA
Inferred from Electronic Annotation
more info
  
involved_in spindle elongation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in basal cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Protein CLASP-1
NP_498649.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    7508178..7515285
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066248.5 → NP_498649.1  Protein CLASP-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498649.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95YF0
    Conserved Domains (1) summary
    pfam12348
    Location:379 → 591
    CLASP_N; CLASP N terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95YF0.1

Gene LinkOut

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