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clk-2 Telomere length regulation protein clk-2 [ Caenorhabditis elegans ]

Gene ID: 176065, updated on 12-Jun-2024

Summary

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Gene symbol
clk-2
Gene description
Telomere length regulation protein clk-2
Locus tag
CELE_C07H6.6
See related
AllianceGenome:WB:WBGene00000537
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable Hsp90 protein binding activity and telomeric DNA binding activity. Involved in several processes, including DNA damage checkpoint signaling; determination of adult lifespan; and response to X-ray. Located in cytoplasm. Is expressed in several structures, including head ganglion. Orthologous to human TELO2 (telomere maintenance 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See clk-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
10
Sequence:
Chromosome: III; NC_003281.10 (7515222..7518524, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class Z Neighboring gene U2 snRNP-associated SURP motif-containing protein Neighboring gene Protein CLASP-1 Neighboring gene RRM domain-containing protein Neighboring gene E3 ubiquitin-protein ligase PPP1R11

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CLK-2/TEL2 is a conserved component of the nonsense-mediated mRNA decay pathway. Guo Y, et al. PLoS One, 2021. PMID 33444416, Free PMC Article
  2. C. elegans clk-2, a gene that limits life span, encodes a telomere length regulator similar to yeast telomere binding protein Tel2p. Lim CS, et al. Curr Biol, 2001 Oct 30. PMID 11696330
  3. Human CLK2 links cell cycle progression, apoptosis, and telomere length regulation. Jiang N, et al. J Biol Chem, 2003 Jun 13. PMID 12670948
  4. The C. elegans maternal-effect gene clk-2 is essential for embryonic development, encodes a protein homologous to yeast Tel2p and affects telomere length. Bénard C, et al. Development, 2001 Oct. PMID 11641227
  5. Regulation of developmental rate and germ cell proliferation in Caenorhabditis elegans by the p53 gene network. Derry WB, et al. Cell Death Differ, 2007 Apr. PMID 17186023

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CLK-2/TEL2 is a conserved component of the nonsense-mediated mRNA decay pathway.
    Title: CLK-2/TEL2 is a conserved component of the nonsense-mediated mRNA decay pathway.
  2. Clk-2 mutants accumulate genomic instability and show a delay of embryonic cell cycle timing.
    Title: Functional dissection of Caenorhabditis elegans CLK-2/TEL2 cell cycle defects during embryogenesis and germline development.
  3. Persistent repair intermediates and/or single-stranded DNA formed during repair of misincorporated uracil are tolerated in the absence of the CLK-2 checkpoint in C. elegans.
    Title: Abrogation of the CLK-2 checkpoint leads to tolerance to base-excision repair intermediates.
  4. DNA damage checkpoint protein clk-2 suppresses the frequency of mutation by ensuring that spontaneous DNA damage is accurately repaired in C. elegans germ cells.
    Title: Mutator phenotype of Caenorhabditis elegans DNA damage checkpoint mutants.
  5. Prolonged life span of Clk mutants cannot be attributed to reduced metabolic rate or an increased activity of the major antioxidant enzymes catalase and SOD.
    Title: No reduction of energy metabolism in Clk mutants.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables Hsp90 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in 'de novo' cotranslational protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to UV IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to X-ray IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere maintenance IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Telomere length regulation protein clk-2
NP_001370399.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    7515222..7518524 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001382917.2 → NP_001370399.1  Telomere length regulation protein clk-2 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95NL2, Q95YE9
    Conserved Domains (1) summary
    pfam10193
    Location:538 → 645
    Telomere_reg-2; Telomere length regulation protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95YE9.2

Gene LinkOut

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