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mtx-2 Metaxin-2 homolog [ Caenorhabditis elegans ]

Gene ID: 176087, updated on 2-Nov-2024

Summary

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Official Symbol
mtx-2
Official Full Name
Metaxin-2 homolog
Primary source
WormBase:WBGene00022516
Locus tag
CELE_ZC97.1
See related
AllianceGenome:WB:WBGene00022516
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in mitochondrion organization. Located in mitochondrion. Orthologous to human MTX2 (metaxin 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mtx-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (7761977..7763603, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Cadherin-3 Neighboring gene ncRNA Neighboring gene Putative serine protease pcp-1 Neighboring gene Putative ATP-dependent RNA helicase ZK686.2 Neighboring gene Putative zinc finger protein ZK686.5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Metaxins are core components of mitochondrial transport adaptor complexes. Zhao Y, et al. Nat Commun, 2021 Jan 4. PMID 33397950, Free PMC Article
  2. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
  3. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
  4. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
  5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Metaxins are core components of mitochondrial transport adaptor complexes.
    Title: Metaxins are core components of mitochondrial transport adaptor complexes.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of SAM complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SAM complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Metaxin-2 homolog
NP_498689.2
  • Confirmed by transcript evidence
NP_871672.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    7761977..7763603 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066288.7 → NP_498689.2  Metaxin-2 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498689.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E9P839, P34599, Q2PWT9, Q8I7F3
    Conserved Domains (2) summary
    cd03079
    Location:26 → 99
    GST_N_Metaxin2; GST_N family, Metaxin subfamily, Metaxin 2; a metaxin 1 binding protein identified through a yeast two-hybrid system using metaxin 1 as the bait. Metaxin 2 shares sequence similarity with metaxin 1 but does not contain a C-terminal mitochondrial outer ...
    cl02776
    Location:129 → 254
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

  2. NM_181943.7 → NP_871672.2  Metaxin-2 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_871672.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34599
    Conserved Domains (1) summary
    cl00388
    Location:26 → 66
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
Nucleotide Protein
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