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kle-2 Condensin-2 complex subunit kle-2 [ Caenorhabditis elegans ]

Gene ID: 176116, updated on 2-Nov-2024

Summary

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Official Symbol
kle-2
Official Full Name
Condensin-2 complex subunit kle-2
Primary source
WormBase:WBGene00016202
Locus tag
CELE_C29E4.2
See related
AllianceGenome:WB:WBGene00016202
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable chromatin binding activity. Involved in mitotic sister chromatid segregation. Predicted to be located in chromosome, centromeric region. Predicted to be part of condensin complex. Predicted to be active in nucleus. Orthologous to human NCAPH2 (non-SMC condensin II complex subunit H2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See kle-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003281.10 (7941717..7945593)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Putative galactocerebrosidase Neighboring gene Protein FMC1 homolog Neighboring gene Glutathione transferase omega-1 Neighboring gene Putative cuticle collagen 90 Neighboring gene Adenylate kinase Neighboring gene DUF2189 domain-containing protein Neighboring gene C6 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. C. elegans Gonad Dissection and Freeze Crack for Immunofluorescence and DAPI Staining. Ananthaswamy D, et al. J Vis Exp, 2022 Sep 16. PMID 36190281, Free PMC Article
  2. Genome-wide analysis of condensin binding in Caenorhabditis elegans. Kranz AL, et al. Genome Biol, 2013. PMID 24125077, Free PMC Article
  3. A global chromatin compaction pathway that represses germline gene expression during starvation. Belew MD, et al. J Cell Biol, 2021 Sep 6. PMID 34128967, Free PMC Article
  4. A highly efficient multifunctional tandem affinity purification approach applicable to diverse organisms. Ma H, et al. Mol Cell Proteomics, 2012 Aug. PMID 22474084, Free PMC Article
  5. Two classes of dosage compensation complex binding elements along Caenorhabditis elegans X chromosomes. Blauwkamp TA, et al. Mol Cell Biol, 2009 Apr. PMID 19188444, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A global chromatin compaction pathway that represses germline gene expression during starvation.
    Title: A global chromatin compaction pathway that represses germline gene expression during starvation.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome condensation IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic sister chromatid segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic sister chromatid separation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
part_of condensin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Condensin-2 complex subunit kle-2
NP_498727.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    7941717..7945593
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066326.9 → NP_498727.2  Condensin-2 complex subunit kle-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498727.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34341
    Conserved Domains (2) summary
    pfam06278
    Location:17 → 110
    CNDH2_N; Condensin II complex subunit CAP-H2 or CNDH2, N-terminal
    pfam16858
    Location:706 → 806
    CNDH2_C; Condensin II complex subunit CAP-H2 or CNDH2, C-term
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34341.2

Gene LinkOut

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