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K12H4.2 Uncharacterized protein [ Caenorhabditis elegans ]

Gene ID: 176135, updated on 12-Jun-2024

Summary

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Gene symbol
K12H4.2
Gene description
Uncharacterized protein
Locus tag
CELE_K12H4.2
See related
AllianceGenome:WB:WBGene00019677
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ribosomal large subunit binding activity. Involved in IRE1-mediated unfolded protein response. Predicted to be active in mitochondrion. Orthologous to human MALSU1 (mitochondrial assembly of ribosomal large subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See K12H4.2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
3
Sequence:
Chromosome: III; NC_003281.10 (8047712..8048464)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Signal peptidase complex subunit 3 Neighboring gene Ribosome biogenesis protein BRX1 homolog Neighboring gene Putative serine protease K12H4.7 Neighboring gene ncRNA Neighboring gene Homeobox protein prospero homolog 1 Neighboring gene ncRNA Neighboring gene tRNA-Pro

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
  2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ribosomal large subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in IRE1-mediated unfolded protein response HEP PubMed 
involved_in negative regulation of ribosome biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Uncharacterized protein
NP_498757.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    8047712..8048464
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066356.4 → NP_498757.2  Uncharacterized protein CELE_K12H4.2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498757.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34523
    Conserved Domains (1) summary
    pfam02410
    Location:65 → 167
    RsfS; Ribosomal silencing factor during starvation
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34523.2

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