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apc-2 Anaphase-promoting complex subunit 2 [ Caenorhabditis elegans ]

Gene ID: 176139, updated on 2-Nov-2024

Summary

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Official Symbol
apc-2
Official Full Name
Anaphase-promoting complex subunit 2
Primary source
WormBase:WBGene00000143
Locus tag
CELE_K06H7.6
See related
AllianceGenome:WB:WBGene00000143
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in metaphase/anaphase transition of mitotic cell cycle and protein K11-linked ubiquitination. Predicted to be part of anaphase-promoting complex. Orthologous to human ANAPC2 (anaphase promoting complex subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See apc-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
15
Sequence:
Chromosome: III; NC_003281.10 (8080629..8083701)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Homeobox protein prospero homolog 1 Neighboring gene ncRNA Neighboring gene tRNA-Pro Neighboring gene Death-promoting deoxyribonuclease Neighboring gene Uncharacterized protein Neighboring gene GTP exchange factor for ARFs 1 Neighboring gene tRNA endonuclease vms-1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Kinesin-1 and cytoplasmic dynein act sequentially to move the meiotic spindle to the oocyte cortex in Caenorhabditis elegans. Ellefson ML, et al. Mol Biol Cell, 2009 Jun. PMID 19357192, Free PMC Article
  2. A high-resolution C. elegans essential gene network based on phenotypic profiling of a complex tissue. Green RA, et al. Cell, 2011 Apr 29. PMID 21529718, Free PMC Article
  3. The Arabidopsis anaphase-promoting complex or cyclosome: molecular and genetic characterization of the APC2 subunit. Capron A, et al. Plant Cell, 2003 Oct. PMID 14508008, Free PMC Article
  4. Cortical granule exocytosis in C. elegans is regulated by cell cycle components including separase. Bembenek JN, et al. Development, 2007 Nov. PMID 17913784, Free PMC Article
  5. A genomewide RNAi screen for genes that affect the stability, distribution and function of P granules in Caenorhabditis elegans. Updike DL, et al. Genetics, 2009 Dec. PMID 19805813, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that accumulation of dynein at poles was kinesin-1 independent and APC dependent, just like dynein driven spindle movements.
    Title: Kinesin-1 and cytoplasmic dynein act sequentially to move the meiotic spindle to the oocyte cortex in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in metaphase/anaphase transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K11-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Anaphase-promoting complex subunit 2
NP_498762.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    8080629..8083701
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066361.7 → NP_498762.2  Anaphase-promoting complex subunit 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498762.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34513, P34514
    Conserved Domains (2) summary
    smart01013
    Location:662 → 723
    APC2; Anaphase promoting complex (APC) subunit 2
    smart00182
    Location:408 → 553
    CULLIN; Cullin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34514.3

Gene LinkOut

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