grp-1 GTP exchange factor for ARFs 1 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: grp-1
Gene description: GTP exchange factor for ARFs 1
Locus tag: CELE_K06H7.4
See related: AllianceGenome:WB:WBGene00001743
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of ARF protein signal transduction and regulation of catalytic activity. Located in midbody and nucleus. Is expressed in intestine; nervous system; rectal gland cell; and somatic cell. Orthologous to several human genes including CYTH1 (cytohesin 1); CYTH3 (cytohesin 3); and CYTH4 (cytohesin 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See grp-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 7

Sequence:: Chromosome: III; NC_003281.10 (8085705..8088449)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GRP-1 controls asymmetric divisions of certain neuroblasts that divide to produce a larger neuronal precursor or neuron and a smaller cell fated to die. GRP-1 interacts with CNT-2, EFA-6 and BRIS-1.
Title: Asymmetric neuroblast divisions producing apoptotic cells require the cytohesin GRP-1 in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K06H7.7 (e-PCR)
- UniSTS:313230

K06H7.4 (e-PCR)
- UniSTS:311440

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of ARF protein signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: GTP exchange factor for ARFs 1

NP_498764.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

8085705..8088449

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066363.4 → NP_498764.1 GTP exchange factor for ARFs 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498764.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34512

UniProtKB/TrEMBL

Q9UB38

Conserved Domains (3) summary

cd00171
Location:60 → 241

Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...

cd01252
Location:261 → 382

PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain

pfam00169
Location:263 → 380

PH; PH domain