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atg-13 Autophagy-related protein 13 homolog [ Caenorhabditis elegans ]

Gene ID: 176150, updated on 2-Nov-2024

Summary

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Official Symbol
atg-13
Official Full Name
Autophagy-related protein 13 homolog
Primary source
WormBase:WBGene00017045
Locus tag
CELE_D2007.5
See related
AllianceGenome:WB:WBGene00017045
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein kinase regulator activity. Predicted to be involved in mitophagy; piecemeal microautophagy of the nucleus; and protein localization to phagophore assembly site. Predicted to be located in axon; cytoplasm; and perikaryon. Predicted to be part of Atg1/ULK1 kinase complex. Predicted to be active in autophagosome; cytosol; and phagophore assembly site. Is expressed in body wall musculature; nerve ring; neurons; and pharyngeal muscle cell. Orthologous to human ATG13 (autophagy related 13). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See atg-13 in Genome Data Viewer
Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003281.10 (8155947..8158190, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene MSP domain-containing protein;Major sperm protein Neighboring gene Uncharacterized protein Neighboring gene Inositol polyphosphate 5-phosphatase Neighboring gene BTB and MATH domain-containing protein 42

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. So Many Roads: the Multifaceted Regulation of Autophagy Induction. Corona Velazquez AF, et al. Mol Cell Biol, 2018 Nov 1. PMID 30126896, Free PMC Article
  2. epg-1 functions in autophagy-regulated processes and may encode a highly divergent Atg13 homolog in C. elegans. Tian E, et al. Autophagy, 2009 Jul. PMID 19377305
  3. Autophagy promotes visceral aging in wild-type C. elegans. Benedetto A, et al. Autophagy, 2019 Apr. PMID 30700231, Free PMC Article
  4. ATG13: just a companion, or an executor of the autophagic program? Alers S, et al. Autophagy, 2014 Jun. PMID 24879146, Free PMC Article
  5. Autophagy and beyond: Unraveling the complexity of UNC-51-like kinase 1 (ULK1) from biological functions to therapeutic implications. Zou L, et al. Acta Pharm Sin B, 2022 Oct. PMID 36213540, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in autophagosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in mitophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in piecemeal microautophagy of the nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Atg1/ULK1 kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
is_active_in phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in phagophore assembly site IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Autophagy-related protein 13 homolog
NP_498782.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    8155947..8158190 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066381.6 → NP_498782.1  Autophagy-related protein 13 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498782.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34379
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34379.1

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