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mig-10 Abnormal cell migration protein 10 [ Caenorhabditis elegans ]

Gene ID: 176168, updated on 2-Nov-2024

Summary

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Official Symbol
mig-10
Official Full Name
Abnormal cell migration protein 10
Primary source
WormBase:WBGene00003243
Locus tag
CELE_F10E9.6
See related
AllianceGenome:WB:WBGene00003243
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables SH3 domain binding activity. Involved in several processes, including egg-laying behavior; lamellipodium assembly; and nervous system development. Located in several cellular components, including growth cone membrane; neuronal cell body membrane; and presynaptic cytosol. Part of filamentous actin. Is expressed in several structures, including anal depressor muscle; intestine; neurons; rectal gland cell; and reproductive system. Orthologous to several human genes including RAPH1 (Ras association (RalGDS/AF-6) and pleckstrin homology domains 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mig-10 in Genome Data Viewer
Location:
chromosome: III
Exon count:
12
Sequence:
Chromosome: III; NC_003281.10 (8279108..8305825)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. C. elegans cell migration gene mig-10 shares similarities with a family of SH2 domain proteins and acts cell nonautonomously in excretory canal development. Manser J, et al. Dev Biol, 1997 Apr 1. PMID 9142991
  2. The Lamellipodin homologue MIG-10 is not essential for dorsal intercalation in the embryonic epidermis of the C. elegans embryo. Serre JM, et al. MicroPubl Biol, 2022. PMID 35136857, Free PMC Article
  3. Abelson interactor-1 (ABI-1) interacts with MRL adaptor protein MIG-10 and is required in guided cell migrations and process outgrowth in C. elegans. McShea MA, et al. Dev Biol, 2013 Jan 1. PMID 23022657, Free PMC Article
  4. Netrin instructs synaptic vesicle clustering through Rac GTPase, MIG-10, and the actin cytoskeleton. Stavoe AK, et al. J Cell Biol, 2012 Apr 2. PMID 22451697, Free PMC Article
  5. UNC-6/netrin and SLT-1/slit guidance cues orient axon outgrowth mediated by MIG-10/RIAM/lamellipodin. Quinn CC, et al. Curr Biol, 2006 May 9. PMID 16563765

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MIG-10 stabilizes invading cell adhesion to basement membrane and is a negative transcriptional target of EGL-43 in C. elegans.
    Title: MIG-10 (Lamellipodin) stabilizes invading cell adhesion to basement membrane and is a negative transcriptional target of EGL-43 in C. elegans.
  2. MIG-10 (lamellipodin), an effector of UNC-40 in neurons has functions independent of UNC-6/UNC-40. Unlike other UNC-40 effectors, its expression is regulated by FOS-1A, a transcription factor that promotes basement membrane breaching.
    Title: MIG-10 (lamellipodin) has netrin-independent functions and is a FOS-1A transcriptional target during anchor cell invasion in C. elegans.
  3. these observations suggest that MIG-10 interacts with ABI-1 and WVE-1 to mediate the UNC-6 and SLT-1 guidance pathways.
    Title: MIG-10 functions with ABI-1 to mediate the UNC-6 and SLT-1 axon guidance signaling pathways.
  4. MIG-10B interacts with Abl-interacting protein-1 (ABI-1)/Abi1, a component of the WAVE complex, to organize the actin cytoskeleton at presynaptic sites and instruct vesicle clustering through SNN-1/Synapsin
    Title: Synaptic vesicle clustering requires a distinct MIG-10/Lamellipodin isoform and ABI-1 downstream from Netrin.
  5. The CED-5 in turn signaled through CED-10/Rac1 and MIG-10/Lamellipodin to organize the actin cytoskeleton in presynaptic regions.
    Title: Netrin instructs synaptic vesicle clustering through Rac GTPase, MIG-10, and the actin cytoskeleton.
  6. Interaction between activated CED-10/Rac1 and MIG-10/lamellipodin triggers local cytoskeletal assembly and polarizes axon outgrowth.
    Title: CED-10/Rac1 mediates axon guidance by regulating the asymmetric distribution of MIG-10/lamellipodin.
  7. During neuronal development, mig-10 and the C. elegans Ena/VASP homolog unc-34 cooperate to guide axons toward UNC-6 (netrin) and away from SLT-1 (Slit).
    Title: MIG-10/lamellipodin and AGE-1/PI3K promote axon guidance and outgrowth in response to slit and netrin.
  8. Genetic analyses indicate that MIG-10/RIAM/lamellipodin functions downstream of the attractive guidance cue UNC-6/netrin and the repulsive guidance cue SLT-1/slit to direct the ventral migration of the AVM and PVM axons in C. elegans.
    Title: UNC-6/netrin and SLT-1/slit guidance cues orient axon outgrowth mediated by MIG-10/RIAM/lamellipodin.
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Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables SH3 domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell projection morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cell projection morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lamellipodium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mesodermal cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in presynapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in presynapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in vulval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of filamentous actin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in growth cone membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
located_in presynaptic cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in presynaptic cytosol IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
Abnormal cell migration protein 10
NP_001367746.1
  • Confirmed by transcript evidence
NP_001370647.1
  • Confirmed by transcript evidence
NP_498821.2
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    8279108..8305825
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001379826.1 → NP_001367746.1  Abnormal cell migration protein 10 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34386, P34400, P34403, Q7JQ80, Q8WT53
    Conserved Domains (2) summary
    cd01259
    Location:452 → 575
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cl28922
    Location:321 → 406
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  2. NM_001382935.2 → NP_001370647.1  Abnormal cell migration protein 10 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    cd01259
    Location:340 → 463
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16138
    Location:209 → 294
    RA_MRL_MIG10; Ras-associating (RA) domain found in Caenorhabditis elegans abnormal cell migration protein 10 (MIG-10) and similar proteins

  3. NM_066420.6 → NP_498821.2  Abnormal cell migration protein 10 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498821.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34400
    Conserved Domains (3) summary
    cd01259
    Location:323 → 446
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam00169
    Location:328 → 436
    PH; PH domain
    cl00155
    Location:196 → 275
    UBQ; Ubiquitin-like proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34400.3

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