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lmbr-1 LIMR family protein R05D3.2 [ Caenorhabditis elegans ]

Gene ID: 176182, updated on 2-Nov-2024

Summary

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Official Symbol
lmbr-1
Official Full Name
LIMR family protein R05D3.2
Primary source
WormBase:WBGene00019877
Locus tag
CELE_R05D3.2
See related
AllianceGenome:WB:WBGene00019877
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in signal transduction. Predicted to be active in plasma membrane. Is expressed in several structures, including enteric muscle; hypodermis; intestine; nervous system; and vulval muscle. Used to study bone development disease. Human ortholog(s) of this gene implicated in Laurin-Sandrow syndrome; acheiropody; and syndactyly type 4. Orthologous to human LMBR1 (limb development membrane protein 1) and LMBR1L (limb development membrane protein 1 like). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lmbr-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003281.10 (8372270..8375220)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Putative zinc finger protein R05D3.3 Neighboring gene ncRNA Neighboring gene Histone-lysine N-methyltransferase met-2 Neighboring gene DNA topoisomerase 2;Putative DNA topoisomerase 2, mitochondrial

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of genetic suppressors for a BSCL2 lipodystrophy pathogenic variant in Caenorhabditis elegans. Bai X, et al. Dis Model Mech, 2024 Jun 1. PMID 38454882, Free PMC Article
  2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
LIMR family protein R05D3.2
NP_001411903.1
  • Confirmed by transcript evidence
NP_498847.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    8372270..8375220
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066446.7 → NP_498847.1  LIMR family protein R05D3.2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498847.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34535
    Conserved Domains (1) summary
    pfam04791
    Location:74 → 693
    LMBR1; LMBR1-like membrane protein

  2. NM_001424973.1 → NP_001411903.1  LIMR family protein R05D3.2 [Caenorhabditis elegans]

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34535.1

Gene LinkOut

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