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cutc-1 Copper homeostasis protein cutC homolog [ Caenorhabditis elegans ]

Gene ID: 176186, updated on 2-Nov-2024

Summary

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Official Symbol
cutc-1
Official Full Name
Copper homeostasis protein cutC homolog
Primary source
WormBase:WBGene00022702
Locus tag
CELE_ZK353.7
See related
AllianceGenome:WB:WBGene00022702
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable copper ion binding activity. Involved in several processes, including egg-laying behavior; response to copper ion; and vulval development. Located in cell junction and striated muscle dense body. Orthologous to human CUTC (cutC copper transporter). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cutc-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
2
Sequence:
Chromosome: III; NC_003281.10 (8402049..8403607, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene Leucine aminopeptidase 1 Neighboring gene UBX domain-containing protein 4 Neighboring gene Cyclin-Y

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Knock down of Caenorhabditis elegans cutc-1 exacerbates the sensitivity toward high levels of copper. Calafato S, et al. Toxicol Sci, 2008 Dec. PMID 18723824
  2. An integrated strategy to study muscle development and myofilament structure in Caenorhabditis elegans. Meissner B, et al. PLoS Genet, 2009 Jun. PMID 19557190, Free PMC Article
  3. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
  4. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
  5. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables copper ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in IRE1-mediated unfolded protein response HEP PubMed 
involved_in copper ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in multicellular organismal reproductive process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to copper ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vulval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell junction HDA PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in striated muscle dense body HDA PubMed 

General protein information

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Preferred Names
Copper homeostasis protein cutC homolog
NP_498855.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    8402049..8403607 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066454.6 → NP_498855.1  Copper homeostasis protein cutC homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498855.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34630
    Conserved Domains (1) summary
    COG3142
    Location:10 → 248
    CutC; Copper homeostasis protein CutC [Inorganic ion transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34630.1

Gene LinkOut

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